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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Rspo1  -  R-spondin homolog (Xenopus laevis)

Mus musculus

Synonyms: Cristin-3, Cysteine-rich and single thrombospondin domain-containing protein 3, R-spondin, R-spondin-1, Roof plate-specific spondin-1, ...
 
 
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High impact information on Rspo1

  • After determining linkage to chromosome 20p13, we identified homozygous or compound heterozygous mutations in the gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, in eight affected families [1].
  • Third, Cristin/R-spondin proteins physically interacted with the extracellular domains of the LRP6 and Fzd8 receptors in vivo and in vitro [2].
  • Furthermore, Cristin/R-spondin proteins possess an intriguing positive modulatory activity on Wnt ligands, possibly through a direct interaction [2].
  • First, conditioned medium containing Cristin/R-spondin proteins effectively induced reporter activity in a TCF-binding site-dependent manner [2].
  • The expression of R-spondin was reduced in Wnt-1/3a double knockout mouse [3].
 

Biological context of Rspo1

  • Transfection of an epitope-tagged R-spondin into COS7 and 293 cells showed its localization in nuclei and medium, suggesting that R-spondin may become secretory or nuclear protein by some processing, while most of other proteins with TSP type 1 domain are secretory proteins [3].
 

Other interactions of Rspo1

  • R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants [3].

References

  1. The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia. Blaydon, D.C., Ishii, Y., O'toole, E.A., Unsworth, H.C., Teh, M.T., R??schendorf, F., Sinclair, C., Hopsu-Havu, V.K., Tidman, N., Moss, C., Watson, R., de Berker, D., Wajid, M., Christiano, A.M., Kelsell, D.P. Nat. Genet. (2006) [Pubmed]
  2. Mouse Cristin/R-spondin Family Proteins Are Novel Ligands for the Frizzled 8 and LRP6 Receptors and Activate beta-Catenin-dependent Gene Expression. Nam, J.S., Turcotte, T.J., Smith, P.F., Choi, S., Yoon, J.K. J. Biol. Chem. (2006) [Pubmed]
  3. R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants. Kamata, T., Katsube, K., Michikawa, M., Yamada, M., Takada, S., Mizusawa, H. Biochim. Biophys. Acta (2004) [Pubmed]
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