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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

XGR  -  XG and CD99 regulator

Homo sapiens

 
 
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High impact information on XGR

  • MIC2 and XGR are the only known pseudoautosomal genes in man [1].
  • The reported effects of XOr and XQ are for red cells, but it is unlikely that other cells and tissues have been studied intensively; propositi with these regulator genes are much rarer than people informative for XGR and In(Lu) [2].
 

Biological context of XGR

  • The co-expression of X-linked MIC2 and XG genes is presumably controlled at the transcriptional level by a single XGR locus in the pseudoautosomal region of sexual chromosomes [3].
 

Other interactions of XGR

  • These findings further support the hypothesis of a single genetic control of CD99 and Xga expression by the XGR locus [3].

References

  1. MIC2: a human pseudoautosomal gene. Goodfellow, P.N., Pym, B., Pritchard, C., Ellis, N., Palmer, M., Smith, M., Goodfellow, P.J. Philos. Trans. R. Soc. Lond., B, Biol. Sci. (1988) [Pubmed]
  2. Regulator genes affecting red cell antigens. Tippett, P. Transfusion medicine reviews. (1990) [Pubmed]
  3. Quantitative analysis of XG blood group and CD99 antigens on human red cells. Fouchet, C., Gane, P., Cartron, J.P., Lopez, C. Immunogenetics (2000) [Pubmed]
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