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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Genes, Regulator

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Disease relevance of Genes, Regulator


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Chemical compound and disease context of Genes, Regulator


Biological context of Genes, Regulator


Anatomical context of Genes, Regulator


Associations of Genes, Regulator with chemical compounds

  • Thus, ATR1 defines the first characterized tryptophan gene regulator in plants, and the atr1D mutation defines a sequence important for ATR1 expression [27].
  • This fusion did not map in any of the known genes of the malA or malB region, but its expression was under control of malT, the positive regulator gene of the maltose regulon [28].
  • Activation of transcription at divergent urea-dependent promoters by the urease gene regulator UreR [29].
  • Sequence analysis of a cloned 5.5-kb DNA fragment obtained from 1 of the imipenem-resistant E. asburiae isolates identified an upstream LysR-type regulator gene that explained inducibility of IMI-2 expression. beta-Lactamase IMI-2 is the first inducible and plasmid-encoded carbapenemase [30].
  • Distribution of mec regulator genes in methicillin-resistant Staphylococcus clinical strains [31].

Gene context of Genes, Regulator

  • Six4, a putative myogenin gene regulator, is not essential for mouse embryonal development [32].
  • Furthermore, these mice had a 24-hour lag in the hepatic expression of the G(1)/S checkpoint regulator genes Ccnd1 and cMyc and increased expression of the IL-1beta cytokine gene [33].
  • Endotoxin treatment of rats and interleukin-1 beta (IL-1 beta) treatment of liver-derived HepG2 cells leads to a marked decline in the nuclear binding activity of a main Ntcp gene regulator, the nuclear receptor heterodimer retinoid X receptor:retinoic acid receptor (RXR:RAR) [34].
  • These nuclear receptors play crucial roles in the regulation of fatty acid metabolism: LXRs activate expression of sterol regulatory element-binding protein 1c (SREBP-1c), a dominant lipogenic gene regulator, whereas PPARalpha promotes fatty acid beta-oxidation genes [35].
  • A 560 bp intergenic region upstream of the nuo locus was followed by a gene (designated lrhA for LysR homologue A) coding for a gene regulator similar to those of the LysR family [36].

Analytical, diagnostic and therapeutic context of Genes, Regulator


  1. Repeat administration of an adenovirus vector encoding cystic fibrosis transmembrane conductance regulator to the nasal epithelium of patients with cystic fibrosis. Zabner, J., Ramsey, B.W., Meeker, D.P., Aitken, M.L., Balfour, R.P., Gibson, R.L., Launspach, J., Moscicki, R.A., Richards, S.M., Standaert, T.A. J. Clin. Invest. (1996) [Pubmed]
  2. Regulation of nitrogen metabolism, starch utilisation and the beta-hbd-adh1 gene cluster in Clostridium acetobutylicum. Woods, D.R., Reid, S.J. FEMS Microbiol. Rev. (1995) [Pubmed]
  3. Glioma/glioblastoma-specific adenoviral gene expression using the nestin gene regulator. Kurihara, H., Zama, A., Tamura, M., Takeda, J., Sasaki, T., Takeuchi, T. Gene Ther. (2000) [Pubmed]
  4. Staphylococcus aureus accessory gene regulator (agr) group II: is there a relationship to the development of intermediate-level glycopeptide resistance? Sakoulas, G., Eliopoulos, G.M., Moellering, R.C., Novick, R.P., Venkataraman, L., Wennersten, C., DeGirolami, P.C., Schwaber, M.J., Gold, H.S. J. Infect. Dis. (2003) [Pubmed]
  5. Identification and purification of novel internalin-related proteins in Listeria monocytogenes and Listeria ivanovii. Lingnau, A., Chakraborty, T., Niebuhr, K., Domann, E., Wehland, J. Infect. Immun. (1996) [Pubmed]
  6. Identification of the mammalian homolog of the splicing regulator Suppressor-of-white-apricot as a thyroid hormone regulated gene. Cuadrado, A., Bernal, J., Muñoz, A. Brain Res. Mol. Brain Res. (1999) [Pubmed]
  7. IME1, a positive regulator gene of meiosis in S. cerevisiae. Kassir, Y., Granot, D., Simchen, G. Cell (1988) [Pubmed]
  8. The heme oxygenase system: a regulator of second messenger gases. Maines, M.D. Annu. Rev. Pharmacol. Toxicol. (1997) [Pubmed]
  9. Phosphorylation of SATB1, a global gene regulator, acts as a molecular switch regulating its transcriptional activity in vivo. Pavan Kumar, P., Purbey, P.K., Sinha, C.K., Notani, D., Limaye, A., Jayani, R.S., Galande, S. Mol. Cell (2006) [Pubmed]
  10. Regulation of T-cell-mediated lympholysis by the murine major histocompatibility complex. II. Control of cytotoxic responses to trinitrophenyl-K and -D self products by H-2K- and H-2D-Region genes. Levy, R.B., Shearer, G.M. J. Exp. Med. (1980) [Pubmed]
  11. Phosphorelay signal transduction: the emerging family of plant response regulators. D'Agostino, I.B., Kieber, J.J. Trends Biochem. Sci. (1999) [Pubmed]
  12. Estrogen-dependent expression of the cystic fibrosis transmembrane regulator gene in a novel uterine epithelial cell line. Rochwerger, L., Dho, S., Parker, L., Foskett, J.K., Buchwald, M. J. Cell. Sci. (1994) [Pubmed]
  13. Molecular analysis of the accessory gene regulator (agr) locus and balance of virulence factor expression in epidemic methicillin-resistant Staphylococcus aureus. Papakyriacou, H., Vaz, D., Simor, A., Louie, M., McGavin, M.J. J. Infect. Dis. (2000) [Pubmed]
  14. Correlation between ceftriaxone resistance of Salmonella enterica serovar Typhimurium and expression of outer membrane proteins OmpW and Ail/OmpX-like protein, which are regulated by BaeR of a two-component system. Hu, W.S., Li, P.C., Cheng, C.Y. Antimicrob. Agents Chemother. (2005) [Pubmed]
  15. Action of CAP on the malT promoter in vitro. Chapon, C., Kolb, A. J. Bacteriol. (1983) [Pubmed]
  16. Nucleotide sequence of a Bacillus subtilis arginine regulatory gene and homology of its product to the Escherichia coli arginine repressor. North, A.K., Smith, M.C., Baumberg, S. Gene (1989) [Pubmed]
  17. The maternally expressed Drosophila gene encoding the chromatin-binding protein BJ1 is a homolog of the vertebrate gene Regulator of Chromatin Condensation, RCC1. Frasch, M. EMBO J. (1991) [Pubmed]
  18. Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Gonzalez-Zulueta, M., Bender, C.M., Yang, A.S., Nguyen, T., Beart, R.W., Van Tornout, J.M., Jones, P.A. Cancer Res. (1995) [Pubmed]
  19. Somatic frameshift mutations in DNA mismatch repair and proapoptosis genes in hereditary nonpolyposis colorectal cancer. Yamamoto, H., Sawai, H., Weber, T.K., Rodriguez-Bigas, M.A., Perucho, M. Cancer Res. (1998) [Pubmed]
  20. Characterization of the regulatory domains of the human skn-1a/Epoc-1/Oct-11 POU transcription factor. Hildesheim, J., Foster, R.A., Chamberlin, M.E., Vogel, J.C. J. Biol. Chem. (1999) [Pubmed]
  21. Regulatory network of acid resistance genes in Escherichia coli. Masuda, N., Church, G.M. Mol. Microbiol. (2003) [Pubmed]
  22. Prolactin modulation of immune and inflammatory responses. Yu-Lee, L.Y. Recent Prog. Horm. Res. (2002) [Pubmed]
  23. Deletion of the SSK1 response regulator gene in Candida albicans contributes to enhanced killing by human polymorphonuclear neutrophils. Du, C., Calderone, R., Richert, J., Li, D. Infect. Immun. (2005) [Pubmed]
  24. An essential two-component signal transduction system in Mycobacterium tuberculosis. Zahrt, T.C., Deretic, V. J. Bacteriol. (2000) [Pubmed]
  25. tbx20, a new vertebrate T-box gene expressed in the cranial motor neurons and developing cardiovascular structures in zebrafish. Ahn, D.G., Ruvinsky, I., Oates, A.C., Silver, L.M., Ho, R.K. Mech. Dev. (2000) [Pubmed]
  26. Vitamin D(3) enhances the expression of I-mfa, an inhibitor of the MyoD family, in osteoblasts. Tsuji, K., Kraut, N., Groudine, M., Noda, M. Biochim. Biophys. Acta (2001) [Pubmed]
  27. A Myb homologue, ATR1, activates tryptophan gene expression in Arabidopsis. Bender, J., Fink, G.R. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  28. Alpha-amylase of Escherichia coli, mapping and cloning of the structural gene, malS, and identification of its product as a periplasmic protein. Freundlieb, S., Boos, W. J. Biol. Chem. (1986) [Pubmed]
  29. Activation of transcription at divergent urea-dependent promoters by the urease gene regulator UreR. D'Orazio, S.E., Thomas, V., Collins, C.M. Mol. Microbiol. (1996) [Pubmed]
  30. Carbapenemase-producing Enterobacteriaceae, U.S. rivers. Aubron, C., Poirel, L., Ash, R.J., Nordmann, P. Emerging Infect. Dis. (2005) [Pubmed]
  31. Distribution of mec regulator genes in methicillin-resistant Staphylococcus clinical strains. Suzuki, E., Kuwahara-Arai, K., Richardson, J.F., Hiramatsu, K. Antimicrob. Agents Chemother. (1993) [Pubmed]
  32. Six4, a putative myogenin gene regulator, is not essential for mouse embryonal development. Ozaki, H., Watanabe, Y., Takahashi, K., Kitamura, K., Tanaka, A., Urase, K., Momoi, T., Sudo, K., Sakagami, J., Asano, M., Iwakura, Y., Kawakami, K. Mol. Cell. Biol. (2001) [Pubmed]
  33. Delayed liver regeneration in peroxisome proliferator-activated receptor-alpha-null mice. Anderson, S.P., Yoon, L., Richard, E.B., Dunn, C.S., Cattley, R.C., Corton, J.C. Hepatology (2002) [Pubmed]
  34. Interleukin-1 beta-mediated suppression of RXR:RAR transactivation of the Ntcp promoter is JNK-dependent. Li, D., Zimmerman, T.L., Thevananther, S., Lee, H.Y., Kurie, J.M., Karpen, S.J. J. Biol. Chem. (2002) [Pubmed]
  35. Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling. Yoshikawa, T., Ide, T., Shimano, H., Yahagi, N., Amemiya-Kudo, M., Matsuzaka, T., Yatoh, S., Kitamine, T., Okazaki, H., Tamura, Y., Sekiya, M., Takahashi, A., Hasty, A.H., Sato, R., Sone, H., Osuga, J., Ishibashi, S., Yamada, N. Mol. Endocrinol. (2003) [Pubmed]
  36. Transcriptional regulation of the proton translocating NADH dehydrogenase genes (nuoA-N) of Escherichia coli by electron acceptors, electron donors and gene regulators. Bongaerts, J., Zoske, S., Weidner, U., Unden, G. Mol. Microbiol. (1995) [Pubmed]
  37. A two-component enhancer-inhibitor transposon mutagenesis system for functional analysis of the Arabidopsis genome. Speulman, E., Metz, P.L., van Arkel, G., te Lintel Hekkert, B., Stiekema, W.J., Pereira, A. Plant Cell (1999) [Pubmed]
  38. Molecular cloning and nucleotide sequence determination of the regulator region of mecA gene in methicillin-resistant Staphylococcus aureus (MRSA). Hiramatsu, K., Asada, K., Suzuki, E., Okonogi, K., Yokota, T. FEBS Lett. (1992) [Pubmed]
  39. HP1 modulates the transcription of cell-cycle regulators in Drosophila melanogaster. De Lucia, F., Ni, J.Q., Vaillant, C., Sun, F.L. Nucleic Acids Res. (2005) [Pubmed]
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