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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ZFAND5  -  zinc finger, AN1-type domain 5

Homo sapiens

Synonyms: AN1-type zinc finger protein 5, ZA20D2, ZFAND5A, ZNF216, Zinc finger A20 domain-containing protein 2, ...
 
 
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Disease relevance of ZFAND5

  • To determine it mutations in ZNF216 might be the cause of hearing loss at the DFNB7/11 locus, we screened the coding region of this gene in DFNB7/11 families by direct sequencing [1].
 

High impact information on ZFAND5

  • ZNF216 Is an A20-like and IkappaB kinase gamma-interacting inhibitor of NFkappaB activation [2].
  • This search identified ZNF216, a zinc finger protein with unknown biological functions [2].
  • We have determined the cDNA sequence and genomic structure of a novel cochlear-expressed gene, ZNF216, that maps to the DFNB7/11 interval [1].
  • Although ectopic expression of full-length ZNF216 abrogated osteoclast differentiation, its truncated forms accelerated it [3].
 

Biological context of ZFAND5

  • Our findings suggest that ZNF216 and A20 have redundant and distinct roles in regulating NFkappaB activation and apoptosis [2].

References

  1. Identification and mutation analysis of a cochlear-expressed, zinc finger protein gene at the DFNB7/11 and dn hearing-loss loci on human chromosome 9q and mouse chromosome 19. Scott, D.A., Greinwald, J.H., Marietta, J.R., Drury, S., Swiderski, R.E., Viñas, A., DeAngelis, M.M., Carmi, R., Ramesh, A., Kraft, M.L., Elbedour, K., Skworak, A.B., Friedman, R.A., Srikumari Srisailapathy, C.R., Verhoeven, K., Van Gamp, G., Lovett, M., Deininger, P.L., Batzer, M.A., Morton, C.C., Keats, B.J., Smith, R.J., Sheffield, V.C. Gene (1998) [Pubmed]
  2. ZNF216 Is an A20-like and IkappaB kinase gamma-interacting inhibitor of NFkappaB activation. Huang, J., Teng, L., Li, L., Liu, T., Li, L., Chen, D., Xu, L.G., Zhai, Z., Shu, H.B. J. Biol. Chem. (2004) [Pubmed]
  3. A RANKL-inducible gene Znf216 in osteoclast differentiation. Hishiya, A., Ikeda, K., Watanabe, K. J. Recept. Signal Transduct. Res. (2005) [Pubmed]
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