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Gene Review

SAP30L  -  SAP30-like

Homo sapiens

Synonyms: FLJ11526, HCV non-structural protein 4A-transactivated protein 2, Histone deacetylase complex subunit SAP30L, NS4ATP2, Sin3 corepressor complex subunit SAP30L, ...
 
 
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High impact information on SAP30L

  • Here, we report that SAP30L, a close homolog of Sin3-associated protein 30 (SAP30), interacts with several components of the Sin3A corepressor complex [1].
  • TGF-beta induces the expression of SAP30L, a novel nuclear protein [2].
  • In the nuclei SAP30L concentrates in small bodies which were shown by immunohistochemistry to colocalize with PML bodies only partially [2].
  • The predicted nuclear localization signal of SAP30L is sufficient for nuclear transport of the protein although mutating it does not completely remove SAP30L from the nuclei [2].
 

Other interactions of SAP30L

  • RESULTS: Differential display analysis resulted in the identification of a novel TGF-beta upregulated mRNA species, the Sin3-associated protein 30-like, SAP30L [2].

References

  1. SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus. Viiri, K.M., Korkeamäki, H., Kukkonen, M.K., Nieminen, L.K., Lindfors, K., Peterson, P., Mäki, M., Kainulainen, H., Lohi, O. Nucleic Acids Res. (2006) [Pubmed]
  2. TGF-beta induces the expression of SAP30L, a novel nuclear protein. Lindfors, K., Viiri, K.M., Niittynen, M., Heinonen, T.Y., Mäki, M., Kainulainen, H. BMC Genomics (2003) [Pubmed]
 
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