Gene Review:
TGFB1 - transforming growth factor, beta 1
Homo sapiens
Synonyms:
CED, DPD1, LAP, TGF-beta-1, TGFB, ...
Fadok,
Cohn,
Büchillier,
Noriko Sakaida,
Guangyu Yang,
Johansson,
Litonjua,
Holmdahl,
DeMeo,
Abitbol,
Diamond,
Bonnel,
Santini,
Go,
Kotseos,
Yasuo Kamiyama,
Homewood,
Laird,
Weiss,
Owen,
Raby,
Andreassen,
Marchant,
Bliss,
Mikio Nishizawa,
Alsner,
Heidenblad,
Fioretos,
Koichi Matsuzaki,
Chung Lee,
Munier,
Schorderet,
Bonny,
Håkansson,
Chupp,
Konowal,
Celedón,
Ferrannini,
Perry,
William J. Catalona,
Qiang Zhang,
McLean,
Yarnold,
Lin Chen,
Shilajit D. Kundu,
Speizer,
Burns,
Michael Pins,
Sylvia,
Katsunori Yoshida,
Wiener,
Solini,
Dickson,
Bratton,
Poncelet,
Janeway,
Yoshiko Uemura,
Haviland,
Masaki Kaibori,
Yinglu Guo,
Silverman,
Norm Smith,
Adekunle A. Raji,
Zhao,
Gorunova,
Herskind,
Kazuichi Okazaki,
Freed,
Thomas L. Jang,
Schnaper,
Hernandez,
Morand,
Toshihito Seki,
Palmer,
Junichi Fujisawa,
Kwiatkowski,
Chegini,
James Kozlowski,
Borko Javonovic,
Auderset,
Menasche,
de Caestecker,
Ximing J. Yang,
Miki Murata,
Höglund,
Go Sekimoto,
Nannipieri,
Henson,
Chapman,
Brian T. Helfand,
Lange,
Paul Lindholm,
Westcott,
Elias,
Bennett,
Lihua J. Zhu,
Jonson,
Reilly,
Overgaard,
- The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Celedón, J.C., Lange, C., Raby, B.A., Litonjua, A.A., Palmer, L.J., DeMeo, D.L., Reilly, J.J., Kwiatkowski, D.J., Chapman, H.A., Laird, N., Sylvia, J.S., Hernandez, M., Speizer, F.E., Weiss, S.T., Silverman, E.K. Hum. Mol. Genet. (2004)
- Combined genetic assessment of transforming growth factor-beta signaling pathway variants may predict breast cancer risk. Kaklamani, V.G., Baddi, L., Liu, J., Rosman, D., Phukan, S., Bradley, C., Hegarty, C., McDaniel, B., Rademaker, A., Oddoux, C., Ostrer, H., Michel, L.S., Huang, H., Chen, Y., Ahsan, H., Offit, K., Pasche, B. Cancer Res. (2005)
- Variant alleles of TGFB1 and TGFBR2 are associated with a decreased risk of gastric cancer in a Chinese population. Jin, G., Wang, L., Chen, W., Hu, Z., Zhou, Y., Tan, Y., Wang, J., Hua, Z., Ding, W., Shen, J., Zhang, Z., Wang, X., Xu, Y., Shen, H. Int. J. Cancer (2007)
- Sp1 is required for transforming growth factor-beta-induced mesenchymal transition and migration in pancreatic cancer cells. Jungert, K., Buck, A., von Wichert, G., Adler, G., König, A., Buchholz, M., Gress, T.M., Ellenrieder, V. Cancer Res. (2007)
- TGF-beta 1 variants in chronic beryllium disease and sarcoidosis. Jonth, A.C., Silveira, L., Fingerlin, T.E., Sato, H., Luby, J.C., Welsh, K.I., Rose, C.S., Newman, L.S., du Bois, R.M., Maier, L.A. J. Immunol. (2007)
- TGF-beta1: a novel target for cardiovascular pharmacology. Redondo, S., Santos-Gallego, C.G., Tejerina, T. Cytokine Growth Factor Rev. (2007)
- Inhibition of TGF-beta with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression. Biswas, S., Guix, M., Rinehart, C., Dugger, T.C., Chytil, A., Moses, H.L., Freeman, M.L., Arteaga, C.L. J. Clin. Invest. (2007)
- Transforming growth factor-beta and the immune response: implications for anticancer therapy. Wrzesinski, S.H., Wan, Y.Y., Flavell, R.A. Clin. Cancer Res. (2007)
- Chronic inflammation associated with hepatitis C virus infection perturbs hepatic transforming growth factor beta signaling, promoting cirrhosis and hepatocellular carcinoma. Matsuzaki, K., Murata, M., Yoshida, K., Sekimoto, G., Uemura, Y., Sakaida, N., Kaibori, M., Kamiyama, Y., Nishizawa, M., Fujisawa, J., Okazaki, K., Seki, T. Hepatology (2007)
- Nuclear factor-kappaB-mediated transforming growth factor-beta-induced expression of vimentin is an independent predictor of biochemical recurrence after radical prostatectomy. Zhang, Q., Helfand, B.T., Jang, T.L., Zhu, L.J., Chen, L., Yang, X.J., Kozlowski, J., Smith, N., Kundu, S.D., Yang, G., Raji, A.A., Javonovic, B., Pins, M., Lindholm, P., Guo, Y., Catalona, W.J., Lee, C. Clin. Cancer Res. (2009)
- Hyaluronan orchestrates transforming growth factor-beta1-dependent maintenance of myofibroblast phenotype. Webber, J., Meran, S., Steadman, R., Phillips, A. J. Biol. Chem. (2009)
- Association studies of transforming growth factor-beta 1 and Alzheimer's disease. Dickson, M.R., Perry, R.T., Wiener, H., Go, R.C. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2005)
- Role of interleukin-6 and transforming growth factor-beta in anorexia nervosa. Pomeroy, C., Eckert, E., Hu, S., Eiken, B., Mentink, M., Crosby, R.D., Chao, C.C. Biol. Psychiatry (1994)
- Anti-TGF-beta strategies for the treatment of chronic liver disease. Breitkopf, K., Haas, S., Wiercinska, E., Singer, M.V., Dooley, S. Alcohol. Clin. Exp. Res. (2005)
- Distribution of endoglin in early human development reveals high levels on endocardial cushion tissue mesenchyme during valve formation. Qu, R., Silver, M.M., Letarte, M. Cell Tissue Res. (1998)
- Differential expression of TGF-beta1 and TGF-beta3 in serosal tissues of human intraperitoneal organs and peritoneal adhesions. Chegini, N., Kotseos, K., Zhao, Y., Bennett, B., McLean, F.W., Diamond, M.P., Holmdahl, L., Burns, J. Hum. Reprod. (2001)
- Asthma: mechanisms of disease persistence and progression. Cohn, L., Elias, J.A., Chupp, G.L. Annu. Rev. Immunol. (2004)
- A trip through my life with an immunological theme. Janeway, C.A. Annu. Rev. Immunol. (2002)
- Regulation of immune responses by TGF-beta. Letterio, J.J., Roberts, A.B. Annu. Rev. Immunol. (1998)
- The CD40 antigen and its ligand. Banchereau, J., Bazan, F., Blanchard, D., Brière, F., Galizzi, J.P., van Kooten, C., Liu, Y.J., Rousset, F., Saeland, S. Annu. Rev. Immunol. (1994)
- Host genetic factors influence disease progression in chronic hepatitis C. Powell, E.E., Edwards-Smith, C.J., Hay, J.L., Clouston, A.D., Crawford, D.H., Shorthouse, C., Purdie, D.M., Jonsson, J.R. Hepatology (2000)
- Prohibitin and Cofilin Are Intracellular Effectors of Transforming Growth Factor {beta} Signaling in Human Prostate Cancer Cells. Zhu, B., Fukada, K., Zhu, H., Kyprianou, N. Cancer Res. (2006)
- Endogenous control of cell cycle progression by autocrine transforming growth factor beta in breast cancer cells. Ammanamanchi, S., Tillekeratne, M.P., Ko, T.C., Brattain, M.G. Cancer Res. (2004)
- Tumor-induced regulation of suppressor macrophage nitric oxide and TNF-alpha production. Role of tumor-derived IL-10, TGF-beta, and prostaglandin E2. Alleva, D.G., Burger, C.J., Elgert, K.D. J. Immunol. (1994)
- Characterization of transforming growth factor-beta (TGF-beta) receptors on BeWo choriocarcinoma cells including the identification of a novel 38-kDa TGF-beta binding glycoprotein. Mitchell, E.J., Lee, K., O'Connor-McCourt, M.D. Mol. Biol. Cell (1992)
- Inhibitors of clathrin-dependent endocytosis enhance TGFbeta signaling and responses. Chen, C.L., Hou, W.H., Liu, I.H., Hsiao, G., Huang, S.S., Huang, J.S. J. Cell. Sci. (2009)
- A mutation affecting the latency-associated peptide of TGFbeta1 in Camurati-Engelmann disease enhances osteoclast formation in vitro. McGowan, N.W., MacPherson, H., Janssens, K., Van Hul, W., Frith, J.C., Fraser, W.D., Ralston, S.H., Helfrich, M.H. J. Clin. Endocrinol. Metab. (2003)
- Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy. Hoffjan, S., Ostrovnaja, I., Nicolae, D., Newman, D.L., Nicolae, R., Gangnon, R., Steiner, L., Walker, K., Reynolds, R., Greene, D., Mirel, D., Gern, J.E., Lemanske, R.F., Ober, C. J. Allergy Clin. Immunol. (2004)
- Pancreatic carcinoma cell lines with SMAD4 inactivation show distinct expression responses to TGFB1. Jonson, T., Heidenblad, M., Håkansson, P., Gorunova, L., Johansson, B., Fioretos, T., Höglund, M. Genes Chromosomes Cancer (2003)
- Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma. Karagiannidis, C., Akdis, M., Holopainen, P., Woolley, N.J., Hense, G., Rückert, B., Mantel, P.Y., Menz, G., Akdis, C.A., Blaser, K., Schmidt-Weber, C.B. J. Allergy Clin. Immunol. (2004)
- Evidence that osteogenic progenitor cells in the human tunica albuginea may originate from stem cells: implications for peyronie disease. Vernet, D., Nolazco, G., Cantini, L., Magee, T.R., Qian, A., Rajfer, J., Gonzalez-Cadavid, N.F. Biol. Reprod. (2005)
- Transforming growth factor B1 stimulated DNA synthesis in the granulosa cells of preantral follicles: negative interaction with epidermal growth factor. Yang, P., Roy, S.K. Biol. Reprod. (2006)
- Histopathological and cellular studies of a case of cutaneous radiation syndrome after accidental chronic exposure to a cesium source. Vozenin-Brotons, M.C., Gault, N., Sivan, V., Tricaud, Y., Dubray, B., Clough, K., Cosset, J.M., Lefaix, J.L., Martin, M. Radiat. Res. (1999)
- High glucose and homocysteine synergistically affect the metalloproteinases-tissue inhibitors of metalloproteinases pattern, but not TGFB expression, in human fibroblasts. Solini, A., Santini, E., Nannipieri, M., Ferrannini, E. Diabetologia (2006)
- Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase. Lin, H.Y., Wang, X.F., Ng-Eaton, E., Weinberg, R.A., Lodish, H.F. Cell (1992)
- Monocyte deactivation in septic patients: restoration by IFN-gamma treatment. Döcke, W.D., Randow, F., Syrbe, U., Krausch, D., Asadullah, K., Reinke, P., Volk, H.D., Kox, W. Nat. Med. (1997)
- Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. Fadok, V.A., Bratton, D.L., Konowal, A., Freed, P.W., Westcott, J.Y., Henson, P.M. J. Clin. Invest. (1998)
- Cholesterol suppresses cellular TGF-beta responsiveness: implications in atherogenesis. Chen, C.L., Liu, I.H., Fliesler, S.J., Han, X., Huang, S.S., Huang, J.S. J. Cell. Sci. (2007)
- Neutrophil elastase converts human immature dendritic cells into transforming growth factor-beta1-secreting cells and reduces allostimulatory ability. Maffia, P.C., Zittermann, S.E., Scimone, M.L., Tateosian, N., Amiano, N., Guerrieri, D., Lutzky, V., Rosso, D., Romeo, H.E., Garcia, V.E., Issekutz, A.C., Chuluyan, H.E. Am. J. Pathol. (2007)
- Polarity of response to transforming growth factor-beta1 in proximal tubular epithelial cells is regulated by beta-catenin. Zhang, M., Lee, C.H., Luo, D.D., Krupa, A., Fraser, D., Phillips, A. J. Biol. Chem. (2007)
- Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts. Asano, Y., Ihn, H., Yamane, K., Kubo, M., Tamaki, K. J. Clin. Invest. (2004)
- Association of the small latent transforming growth factor-beta with an eight cysteine repeat of its binding protein LTBP-1. Saharinen, J., Taipale, J., Keski-Oja, J. EMBO J. (1996)
- Growth inhibition by transforming growth factor beta (TGF-beta) type I is restored in TGF-beta-resistant hepatoma cells after expression of TGF-beta receptor type II cDNA. Inagaki, M., Moustakas, A., Lin, H.Y., Lodish, H.F., Carr, B.I. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Ski acts as a co-repressor with Smad2 and Smad3 to regulate the response to type beta transforming growth factor. Xu, W., Angelis, K., Danielpour, D., Haddad, M.M., Bischof, O., Campisi, J., Stavnezer, E., Medrano, E.E. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Modulation of the functional binding sites for TGF-beta on the type II receptor leads to suppression of TGF-beta signaling. Shimanuki, T., Hara, T., Furuya, T., Imamura, T., Miyazono, K. Oncogene (2007)
- Modulation of endogenous Smad expression in normal skin fibroblasts by transforming growth factor-beta. Mori, Y., Chen, S.J., Varga, J. Exp. Cell Res. (2000)
- The transforming growth factor-beta/SMAD signaling pathway is present and functional in human mesangial cells. Poncelet, A.C., de Caestecker, M.P., Schnaper, H.W. Kidney Int. (1999)
- Transforming growth factor-beta-mediated mast cell migration depends on mitogen-activated protein kinase activity. Olsson, N., Piek, E., Sundström, M., ten Dijke, P., Nilsson, G. Cell. Signal. (2001)
- High glucose-induced transforming growth factor beta1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells. Kolm-Litty, V., Sauer, U., Nerlich, A., Lehmann, R., Schleicher, E.D. J. Clin. Invest. (1998)
- Biochemical evidence for the autophosphorylation and transphosphorylation of transforming growth factor beta receptor kinases. Chen, F., Weinberg, R.A. Proc. Natl. Acad. Sci. U.S.A. (1995)
- A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease. Seki, S., Kawaguchi, Y., Chiba, K., Mikami, Y., Kizawa, H., Oya, T., Mio, F., Mori, M., Miyamoto, Y., Masuda, I., Tsunoda, T., Kamata, M., Kubo, T., Toyama, Y., Kimura, T., Nakamura, Y., Ikegawa, S. Nat. Genet. (2005)
- Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein. Stroschein, S.L., Wang, W., Zhou, S., Zhou, Q., Luo, K. Science (1999)
- Correlation of fibrosis and transforming growth factor-beta type 2 levels in the eye. Connor, T.B., Roberts, A.B., Sporn, M.B., Danielpour, D., Dart, L.L., Michels, R.G., de Bustros, S., Enger, C., Kato, H., Lansing, M. J. Clin. Invest. (1989)
- Akt interacts directly with Smad3 to regulate the sensitivity to TGF-beta induced apoptosis. Conery, A.R., Cao, Y., Thompson, E.A., Townsend, C.M., Ko, T.C., Luo, K. Nat. Cell Biol. (2004)
- Cytoplasmic SnoN in normal tissues and nonmalignant cells antagonizes TGF-beta signaling by sequestration of the Smad proteins. Krakowski, A.R., Laboureau, J., Mauviel, A., Bissell, M.J., Luo, K. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Inhibitory cytokine circuits involving transforming growth factor-beta, interferon-gamma, and interleukin-2 in human monocyte activation. Espinoza-Delgado, I., Bosco, M.C., Musso, T., Mood, K., Ruscetti, F.W., Longo, D.L., Varesio, L. Blood (1994)
- Interactome of transforming growth factor-beta type I receptor (TbetaRI): inhibition of TGFbeta signaling by Epac1. Conrotto, P., Yakymovych, I., Yakymovych, M., Souchelnytskyi, S. J. Proteome Res. (2007)
- Mechanisms of tissue inhibitor of metalloproteinase 1 augmentation by IL-13 on TGF-beta 1-stimulated primary human fibroblasts. Zhou, X., Hu, H., Huynh, M.L., Kotaru, C., Balzar, S., Trudeau, J.B., Wenzel, S.E. J. Allergy Clin. Immunol. (2007)
- Signaling by ALK5 mediates TGF-beta-induced ET-1 expression in endothelial cells: a role for migration and proliferation. Castañares, C., Redondo-Horcajo, M., Magán-Marchal, N., ten Dijke, P., Lamas, S., Rodríguez-Pascual, F. J. Cell. Sci. (2007)
- AMP-activated protein kinase inhibits transforming growth factor-beta-induced Smad3-dependent transcription and myofibroblast transdifferentiation. Mishra, R., Cool, B.L., Laderoute, K.R., Foretz, M., Viollet, B., Simonson, M.S. J. Biol. Chem. (2008)
- TGF-beta induces growth arrest in Burkitt lymphoma cells via transcriptional repression of E2F-1. Spender, L.C., Inman, G.J. J. Biol. Chem. (2009)
- Runx1 is a co-activator with FOXO3 to mediate transforming growth factor beta (TGFbeta)-induced Bim transcription in hepatic cells. Wildey, G.M., Howe, P.H. J. Biol. Chem. (2009)
- Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4. Hata, A., Lo, R.S., Wotton, D., Lagna, G., Massagué, J. Nature (1997)
- The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation. Feng, X.H., Zhang, Y., Wu, R.Y., Derynck, R. Genes Dev. (1998)
- Tumor necrosis factor alpha is a potent synergistic factor for the proliferation of primitive human hematopoietic progenitor cells and induces resistance to transforming growth factor beta but not to interferon gamma. Snoeck, H.W., Weekx, S., Moulijn, A., Lardon, F., Lenjou, M., Nys, G., Van Ranst, P.C., Van Bockstaele, D.R., Berneman, Z.N. J. Exp. Med. (1996)
- Atopic dermatitis is associated with a low-producer transforming growth factor beta(1) cytokine genotype. Arkwright, P.D., Chase, J.M., Babbage, S., Pravica, V., David, T.J., Hutchinson, I.V. J. Allergy Clin. Immunol. (2001)
- Genomic characterization and embryonic expression of the mouse Bigh3 (Tgfbi) gene. Schorderet, D.F., Menasche, M., Morand, S., Bonnel, S., Büchillier, V., Marchant, D., Auderset, K., Bonny, C., Abitbol, M., Munier, F.L. Biochem. Biophys. Res. Commun. (2000)
- TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early breast cancer. Andreassen, C.N., Alsner, J., Overgaard, J., Herskind, C., Haviland, J., Owen, R., Homewood, J., Bliss, J., Yarnold, J. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. (2005)