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Gene Review:

IPO4 - importin 4

Homo sapiens

Synonyms: FLJ23338, IMP4B, Imp4, Imp4b, Importin-4, ...

Miyauchi, Y. et al., Rokhlin, O.W. et al., Baryshnikov AYu, n.u.l.l. et al., Sidorenko, S.P. et al.

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High impact information on IPO4

The agonistic anti-Fas monoclonal antibody (IPO-4) induced apoptosis in only two of six cell lines investigated, PC3 and ALVA31 [1].
Therefore, we performed the yeast two-hybrid screening using VDR-(4-232) as the bait to explore the molecules responsible for ligand-independent nuclear translocation of VDR, and have identified importin 4 as an interacting protein [2].
CD95 antigen expression was studied by monoclonal antibodies (MoAbs) IPO-4 in indirect immunofluorescence analysis [3].
MAb IPO-4 detected an antigen of activated T and B lymphocytes [4].

References

Fas-mediated apoptosis in human prostatic carcinoma cell lines. Rokhlin, O.W., Bishop, G.A., Hostager, B.S., Waldschmidt, T.J., Sidorenko, S.P., Pavloff, N., Kiefer, M.C., Umansky, S.R., Glover, R.A., Cohen, M.B. Cancer Res. (1997) [Pubmed]
Importin 4 is responsible for ligand-independent nuclear translocation of vitamin D receptor. Miyauchi, Y., Michigami, T., Sakaguchi, N., Sekimoto, T., Yoneda, Y., Pike, J.W., Yamagata, M., Ozono, K. J. Biol. Chem. (2005) [Pubmed]
CD95 (FAS/APO-1) antigen is a new prognostic marker of blast cells of acute lymphoblastic leukaemia patients. Baryshnikov AYu, n.u.l.l., Polosukhina, E.R., Tupitsin, N.N., Gavrikova, N.V., Andreeva LYu, n.u.l.l., Zabotina, T.N., Mayakova, S.A., Kurmashov, V.I., Syrkin, A.B., Kadagidze, Z.G., Blochin DYu, n.u.l.l., Shishkin YuV, n.u.l.l. Adv. Exp. Med. Biol. (1999) [Pubmed]
Monoclonal antibodies of IPO series against B cell differentiation antigens in leukemia and lymphoma immunophenotyping. Sidorenko, S.P., Vetrova, E.P., Yurchenko, O.V., Berdova, A.G., Shlapatskaya, L.N., Gluzman, D.F. Neoplasma (1992) [Pubmed]

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AgaP_AGAP006942	Anopheles gambiae str. PEST
AT4G27640	Arabidopsis thaliana
AGOS_AGL298C	Ashbya gossypii ATCC 10895
IPO4	Bos taurus
IPO4	Canis lupus familiaris
ipo4	Danio rerio
CG32164	Drosophila melanogaster
CG32165	Drosophila melanogaster
KLLA0E20769g	Kluyveromyces lactis NRRL Y-1140
IPO4	Macaca mulatta
MGG_16711	Magnaporthe oryzae 70-15
Ipo4	Mus musculus
NCU05650	Neurospora crassa OR74A
IPO4	Pan troglodytes
Ipo4	Rattus norvegicus
KAP123	Saccharomyces cerevisiae S288c
kap123	Schizosaccharomyces pombe 972h-
ipo4	Xenopus (Silurana) tropicalis

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