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Gene Review:

PPCS - phosphopantothenoylcysteine synthetase

Homo sapiens

Synonyms: COAB, FLJ11838, PPC synthetase, Phosphopantothenate--cysteine ligase, Phosphopantothenoylcysteine synthetase

Mitchell, C.K. et al., O'Toole, N. et al., Stanitzek, S. et al.

Mitchell, Smoger, Pfeifer, Vogel, Pandit, Donnelly, Garrison, Rothschild,

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Disease relevance of PPCS

Structural basis of CTP-dependent peptide bond formation in coenzyme A biosynthesis catalyzed by Escherichia coli PPC synthetase [1].

High impact information on PPCS

The risk factors found to be higher among those with PPCs compared with those without PPCs were postoperative nasogastric intubation (81% vs 16%, P<.001), preoperative sputum production (56% vs 21%, P=.005), and longer anesthesia duration (480 vs 309 minutes, P<.001) [2].

Associations of PPCS with chemical compounds

The determination of the crystal structure of human phosphopantothenoylcysteine synthetase completes our knowledge of the enzyme structures involved in all steps of coenzyme A biosynthesis [3].

References

Structural basis of CTP-dependent peptide bond formation in coenzyme A biosynthesis catalyzed by Escherichia coli PPC synthetase. Stanitzek, S., Augustin, M.A., Huber, R., Kupke, T., Steinbacher, S. Structure (Camb.) (2004) [Pubmed]
Multivariate analysis of factors associated with postoperative pulmonary complications following general elective surgery. Mitchell, C.K., Smoger, S.H., Pfeifer, M.P., Vogel, R.L., Pandit, M.K., Donnelly, P.J., Garrison, R.N., Rothschild, M.A. Archives of surgery (Chicago, Ill. : 1960) (1998) [Pubmed]
The final player in the coenzyme A biosynthetic pathway. O'Toole, N., Cygler, M. Structure (Camb.) (2003) [Pubmed]

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AgaP_AGAP004311	Anopheles gambiae str. PEST
AT5G02080	Arabidopsis thaliana
COAB	Arabidopsis thaliana
AGOS_AGR391W	Ashbya gossypii ATCC 10895
Y71H2AM.6	Caenorhabditis elegans
PPCS	Canis lupus familiaris
ppcs	Danio rerio
Ppcs	Drosophila melanogaster
PPCS	Gallus gallus
KLLA0E08757g	Kluyveromyces lactis NRRL Y-1140
PPCS	Macaca mulatta
MGG_17982	Magnaporthe oryzae 70-15
Ppcs	Mus musculus
NCU09090	Neurospora crassa OR74A
Os02g0575200	Oryza sativa Japonica Group
Os08g0176100	Oryza sativa Japonica Group
PPCS	Pan troglodytes
Ppcs	Rattus norvegicus
CAB2	Saccharomyces cerevisiae S288c
SPCC4B3.18	Schizosaccharomyces pombe 972h-
ppcs	Xenopus (Silurana) tropicalis

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