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Gene Review

PALB2  -  partner and localizer of BRCA2

Homo sapiens

Synonyms: FANCN, FLJ21816, PNCA3, Partner and localizer of BRCA2
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Disease relevance of PALB2


Physical interactions of PALB2

  • Although damage-induced RAD51 foci formation and mitomycin C sensitivity appeared normal in MRG15-binding defective PALB2 mutants, these cells exhibited a significant increase in gene conversion rates [2].
  • This stimulation occurs through reinforcing biochemical mechanisms, as PALB2 alleviates inhibition by RPA and stabilizes the RAD51 filament [3].

Other interactions of PALB2

  • This stimulation stems from the ability of PALB2 to function with RAD51 and RAD51AP1 to assemble the synaptic complex [4].


  1. The breast cancer susceptibility mutation PALB2 1592delT is associated with an aggressive tumor phenotype. Heikkinen, T., Kärkkäinen, H., Aaltonen, K., Milne, R.L., Heikkilä, P., Aittomäki, K., Blomqvist, C., Nevanlinna, H. Clin. Cancer Res. (2009) [Pubmed]
  2. MRG15 is a novel PALB2-interacting factor involved in homologous recombination. Sy, S.M., Huen, M.S., Chen, J. J. Biol. Chem. (2009) [Pubmed]
  3. Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination. Buisson, R., Dion-Côté, A.M., Coulombe, Y., Launay, H., Cai, H., Stasiak, A.Z., Stasiak, A., Xia, B., Masson, J.Y. Nat. Struct. Mol. Biol. (2010) [Pubmed]
  4. Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2. Dray, E., Etchin, J., Wiese, C., Saro, D., Williams, G.J., Hammel, M., Yu, X., Galkin, V.E., Liu, D., Tsai, M.S., Sy, S.M., Schild, D., Egelman, E., Chen, J., Sung, P. Nat. Struct. Mol. Biol. (2010) [Pubmed]
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