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Gene Review

RAD51AP1  -  RAD51 associated protein 1

Homo sapiens

Synonyms: PIR51, RAD51-associated protein 1, RAD51-interacting protein
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Disease relevance of RAD51AP1


High impact information on RAD51AP1

  • Our results suggest that FANCD2 mediates double strand DNA break repair independently of Rad51-associated homologous recombination [2].
  • During a search for Rad51-associated proteins in CHO nuclear extracts of S-phase cells by mass spectrometry of proteins immunoprecipitated with Rad51 antibodies, we identified a centrosomal protein, gamma-tubulin [4].
  • Pir51 mRNA is expressed in a number of human organs, most notably in testis, thymus, colon and small intestine [1].
  • The Pir51 protein may represent a new member of the multiprotein complexes postulated to carry out homologous recombination and DNA repair in mammalian cells [1].
  • The Pir51 gene locus was mapped to chromosome 12p13.1-13 [1].

Biological context of RAD51AP1


Physical interactions of RAD51AP1

  • RAD51AP2, a novel vertebrate- and meiotic-specific protein, shares a conserved RAD51-interacting C-terminal domain with RAD51AP1/PIR51 [5].

Other interactions of RAD51AP1


  1. A novel nucleic acid-binding protein that interacts with human rad51 recombinase. Kovalenko, O.V., Golub, E.I., Bray-Ward, P., Ward, D.C., Radding, C.M. Nucleic Acids Res. (1997) [Pubmed]
  2. Fanconi anemia complementation group D2 (FANCD2) functions independently of BRCA2- and RAD51-associated homologous recombination in response to DNA damage. Ohashi, A., Zdzienicka, M.Z., Chen, J., Couch, F.J. J. Biol. Chem. (2005) [Pubmed]
  3. Pir51, a Rad51-interacting protein with high expression in aggressive lymphoma, controls mitomycin C sensitivity and prevents chromosomal breaks. Henson, S.E., Tsai, S.C., Malone, C.S., Soghomonian, S.V., Ouyang, Y., Wall, R., Marahrens, Y., Teitell, M.A. Mutat. Res. (2006) [Pubmed]
  4. DNA damage induce gamma-tubulin-RAD51 nuclear complexes in mammalian cells. Lesca, C., Germanier, M., Raynaud-Messina, B., Pichereaux, C., Etievant, C., Emond, S., Burlet-Schiltz, O., Monsarrat, B., Wright, M., Defais, M. Oncogene (2005) [Pubmed]
  5. RAD51AP2, a novel vertebrate- and meiotic-specific protein, shares a conserved RAD51-interacting C-terminal domain with RAD51AP1/PIR51. Kovalenko, O.V., Wiese, C., Schild, D. Nucleic Acids Res. (2006) [Pubmed]
  6. Identification of differentially expressed genes in HPV-positive and HPV-negative oropharyngeal squamous cell carcinomas. Martinez, I., Wang, J., Hobson, K.F., Ferris, R.L., Khan, S.A. Eur. J. Cancer (2007) [Pubmed]
  7. Regulation of double-strand break-induced mammalian homologous recombination by UBL1, a RAD51-interacting protein. Li, W., Hesabi, B., Babbo, A., Pacione, C., Liu, J., Chen, D.J., Nickoloff, J.A., Shen, Z. Nucleic Acids Res. (2000) [Pubmed]
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