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Gene Review

PIGZ  -  phosphatidylinositol glycan anchor...

Homo sapiens

Synonyms: FLJ12768, GPI mannosyltransferase 4, GPI mannosyltransferase IV, GPI-MT-IV, MGC52163, ...
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High impact information on PIGZ

  • Correspondingly, increasing expression of hSMP3 in cultured HeLa cells causes abundant formation of three putative tetramannosyl (Man(4))-GPIs [1].
  • Northern analysis of mRNA from human tissues and cell lines indicates that hSMP3 is expressed in most tissues, with the highest levels in brain and colon, but its mRNA is nearly absent from cultured human cell lines [1].


  1. Human Smp3p adds a fourth mannose to yeast and human glycosylphosphatidylinositol precursors in vivo. Taron, B.W., Colussi, P.A., Wiedman, J.M., Orlean, P., Taron, C.H. J. Biol. Chem. (2004) [Pubmed]
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