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Gene Review:

COX1 -

Candida albicans SC5314

Athikomkulchai, S. et al., Lin, J. et al.

Lin, Opoku, Geheeb-Keller, Hutchings, Terblanche, Jäger, van Staden,

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High impact information on COX1

Compounds 1-2 (IC(50) 2.11-4.95 microg/ml) exhibited potent but non-selective activity against the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) whereas 3 (IC(50) 1.88 microg/ml) preferentially inhibited the enzyme COX-2 [1].
Of the twenty-nine crude extracts assayed for prostaglandin synthesis inhibitors, only five methanolic extracts of Cyphostemma natalitium-root, Rhoicissus digitata-leaf, R. rhomboidea-root, R. tomentosa-leaf/stem and R. tridentata-root showed significant inhibition of cyclo-oxygenase (COX-1) [2].

Other interactions of COX1

COX-1, COX-2 inhibitors and antifungal agents from Croton hutchinsonianus [1].

References

COX-1, COX-2 inhibitors and antifungal agents from Croton hutchinsonianus. Athikomkulchai, S., Prawat, H., Thasana, N., Ruangrungsi, N., Ruchirawat, S. Chem. Pharm. Bull. (2006) [Pubmed]
Preliminary screening of some traditional zulu medicinal plants for anti-inflammatory and anti-microbial activities. Lin, J., Opoku, A.R., Geheeb-Keller, M., Hutchings, A.D., Terblanche, S.E., Jäger, A.K., van Staden, J. Journal of ethnopharmacology. (1999) [Pubmed]

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