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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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COX-1, COX-2 inhibitors and antifungal agents from Croton hutchinsonianus.

Two new compounds, 3'-(4''-hydroxy-3'',5''-dimethoxyphenyl)-propyl benzoate (1) and 3'-(4''-hydroxyphenyl)-propyl benzoate (3) together with known compounds, 3'-(4''-hydroxy-3''-methoxyphenyl)-propyl benzoate (2), poilaneic acid (4), farnesyl acetone (5) and 4-hydroxybenzaldehyde (6) were isolated and identified from the branches of Croton hutchinsonianus. Their structures were determined by spectroscopic methods. The three phenylpropyl benzoates (1-3) were found to exhibit antifungal activity against Candida albicans (IC(50) 5.36-11.41 microg/ml). Compounds 1-2 (IC(50) 2.11-4.95 microg/ml) exhibited potent but non-selective activity against the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) whereas 3 (IC(50) 1.88 microg/ml) preferentially inhibited the enzyme COX-2.[1]

References

  1. COX-1, COX-2 inhibitors and antifungal agents from Croton hutchinsonianus. Athikomkulchai, S., Prawat, H., Thasana, N., Ruangrungsi, N., Ruchirawat, S. Chem. Pharm. Bull. (2006) [Pubmed]
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