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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Gpr12  -  G protein-coupled receptor 12

Rattus norvegicus

Synonyms: G-protein coupled receptor 12, Gpcr12, R334
 
 
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High impact information on Gpcr12

  • A block in spontaneous oocyte maturation was also induced when Gpr3 or Gpr12 mRNA was injected into mouse oocytes [1].
  • It is interesting that substituting the basic amino acids, K333/K334/R335, with three other basic residues, R333/R334/K335, did not change the maximal CCK-8-simulated inositol phosphate formation and the amplitude of CCK-8-evoked Ca(2+)-dependent Cl- currents [2].
 

Anatomical context of Gpcr12

  • We propose that the cAMP levels required for maintaining meiotic arrest in mouse and rat oocytes are dependent on the expression of Gpr3 and/or Gpr12 [1].

References

  1. The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes. Hinckley, M., Vaccari, S., Horner, K., Chen, R., Conti, M. Dev. Biol. (2005) [Pubmed]
  2. Basic amino acids at the C-terminus of the third intracellular loop are required for the activation of phospholipase C by cholecystokinin-B receptors. Wang, H.L. J. Neurochem. (1997) [Pubmed]
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