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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

MyoA  -  myosin A

Plasmodium falciparum 3D7

 
 
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High impact information on PF13_0233

  • Recombinant PfMAP kinase autophosphorylates on both the tyrosine and threonine residues within the TXY motif, and readily phosphorylates myelin basic protein as exogenous substrate [1].
  • Wild-type PfMAP kinase expressed in COS-7 (SV40 transformed African green monkey kidney) cells seemed to induce apoptosis in these cells [1].
  • Here, we show that MTIP is expressed in Plasmodium falciparum merozoites, localises to the periphery of the cell and is present in a complex with myosin A. The MTIP-myosin A tail interaction has a Kd of 235 nM and calcium ions do not play a role in modulating the binding affinity of the two molecules, despite reports of a predicted EF-hand in MTIP [2].
 

Associations of PF13_0233 with chemical compounds

  • The 40 kDa and 80 kDa forms are tyrosine phosphorylated, indicating that they represent the active forms of the PfMAP kinase [1].

References

  1. Characterization of a mitogen-activated protein (MAP) kinase from Plasmodium falciparum. Graeser, R., Küry, P., Franklin, R.M., Kappes, B. Mol. Microbiol. (1997) [Pubmed]
  2. The MTIP-myosin A complex in blood stage malaria parasites. Green, J.L., Martin, S.R., Fielden, J., Ksagoni, A., Grainger, M., Yim Lim, B.Y., Molloy, J.E., Holder, A.A. J. Mol. Biol. (2006) [Pubmed]
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