The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

AmbotzHAA1166     (2S,3R)-2-amino-3-hydroxy- butanamide

Synonyms: AKOS006350428, AC1L9FO4, 49705-99-9, EINECS 256-437-4, (2S,3R)-2-amino-3-hydroxybutanamide, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of threonine

 

Psychiatry related information on threonine

 

High impact information on threonine

  • This network involves receptor serine/threonine kinases at the cell surface and their substrates, the SMAD proteins, which move into the nucleus, where they activate target gene transcription in association with DNA-binding partners [11].
  • The 20S (700-kDa) proteasome contains multiple peptidase activities that function through a new type of proteolytic mechanism involving a threonine active site [12].
  • The protein serine/threonine phosphatase protein phosphatase-1 (PP1) is a ubiquitous eukaryotic enzyme that regulates a variety of cellular processes through the dephosphorylation of dozens of substrates [13].
  • Calcineurin is a eukaryotic Ca(2+)- and calmodulin-dependent serine/threonine protein phosphatase [14].
  • This review deals with the influence of serine/threonine-specific protein phosphatases on the function of ion channels in the plasma membrane of excitable tissues [15].
 

Chemical compound and disease context of threonine

 

Biological context of threonine

 

Anatomical context of threonine

 

Associations of threonine with other chemical compounds

 

Gene context of threonine

 

Analytical, diagnostic and therapeutic context of threonine

References

  1. A gene encoding a protein serine/threonine kinase is required for normal development of M. xanthus, a gram-negative bacterium. Muñoz-Dorado, J., Inouye, S., Inouye, M. Cell (1991) [Pubmed]
  2. Two distinct Pseudomonas effector proteins interact with the Pto kinase and activate plant immunity. Kim, Y.J., Lin, N.C., Martin, G.B. Cell (2002) [Pubmed]
  3. Linkage of the angiotensinogen gene to essential hypertension. Caulfield, M., Lavender, P., Farrall, M., Munroe, P., Lawson, M., Turner, P., Clark, A.J. N. Engl. J. Med. (1994) [Pubmed]
  4. Effect of the myotonic dystrophy (DM) mutation on mRNA levels of the DM gene. Sabouri, L.A., Mahadevan, M.S., Narang, M., Lee, D.S., Surh, L.C., Korneluk, R.G. Nat. Genet. (1993) [Pubmed]
  5. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Jenne, D.E., Reimann, H., Nezu, J., Friedel, W., Loff, S., Jeschke, R., Müller, O., Back, W., Zimmer, M. Nat. Genet. (1998) [Pubmed]
  6. Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use. Chiang, K.P., Gerber, A.L., Sipe, J.C., Cravatt, B.F. Hum. Mol. Genet. (2004) [Pubmed]
  7. Tracking of Alzheimer's disease progression with cerebrospinal fluid tau protein phosphorylated at threonine 231. Hampel, H., Buerger, K., Kohnken, R., Teipel, S.J., Zinkowski, R., Moeller, H.J., Rapoport, S.I., Davies, P. Ann. Neurol. (2001) [Pubmed]
  8. Serine/threonine kinases as molecular targets of antidepressants: implications for pharmacological treatment and pathophysiology of affective disorders. Popoli, M., Mori, S., Brunello, N., Perez, J., Gennarelli, M., Racagni, G. Pharmacol. Ther. (2001) [Pubmed]
  9. Dissociation between CSF total tau and tau protein phosphorylated at threonine 231 in Creutzfeldt-Jakob disease. Buerger, K., Otto, M., Teipel, S.J., Zinkowski, R., Blennow, K., DeBernardis, J., Kerkman, D., Schröder, J., Schönknecht, P., Cepek, L., McCulloch, C., Möller, H.J., Wiltfang, J., Kretzschmar, H., Hampel, H. Neurobiol. Aging (2006) [Pubmed]
  10. Is the early increase in leptinemia one of the anorectic signals induced by an essential amino acid-deficient diet in the rat? Feurté, S., Nicolaïdis, S., Gerozissis, K. Endocrinology (2000) [Pubmed]
  11. TGF-beta signal transduction. Massagué, J. Annu. Rev. Biochem. (1998) [Pubmed]
  12. Structure and functions of the 20S and 26S proteasomes. Coux, O., Tanaka, K., Goldberg, A.L. Annu. Rev. Biochem. (1996) [Pubmed]
  13. Functional diversity of protein phosphatase-1, a cellular economizer and reset button. Ceulemans, H., Bollen, M. Physiol. Rev. (2004) [Pubmed]
  14. Calcineurin: form and function. Rusnak, F., Mertz, P. Physiol. Rev. (2000) [Pubmed]
  15. Effects of serine/threonine protein phosphatases on ion channels in excitable membranes. Herzig, S., Neumann, J. Physiol. Rev. (2000) [Pubmed]
  16. A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma. Hofstra, R.M., Landsvater, R.M., Ceccherini, I., Stulp, R.P., Stelwagen, T., Luo, Y., Pasini, B., Höppener, J.W., van Amstel, H.K., Romeo, G. Nature (1994) [Pubmed]
  17. Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virus. Shih, T.Y., Papageorge, A.G., Stokes, P.E., Weeks, M.O., Scolnick, E.M. Nature (1980) [Pubmed]
  18. Role of the ceramide-signaling pathway in cytokine responses to P-fimbriated Escherichia coli. Hedlund, M., Svensson, M., Nilsson, A., Duan, R.D., Svanborg, C. J. Exp. Med. (1996) [Pubmed]
  19. Molecular basis of fibrinogen Naples associated with defective thrombin binding and thrombophilia. Homozygous substitution of B beta 68 Ala----Thr. Koopman, J., Haverkate, F., Lord, S.T., Grimbergen, J., Mannucci, P.M. J. Clin. Invest. (1992) [Pubmed]
  20. Hemoglobin Rahere, a human hemoglobin variant with amino acid substitution at the 2,3-diphosphoglycerate binding site. Functional consequences of the alteration and effects of bezafibrate on the oxygen bindings. Sugihara, J., Imamura, T., Nagafuchi, S., Bonaventura, J., Bonaventura, C., Cashon, R. J. Clin. Invest. (1985) [Pubmed]
  21. Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth. Mumby, M.C., Walter, G. Physiol. Rev. (1993) [Pubmed]
  22. The Cdk-activating kinase (CAK) from budding yeast. Kaldis, P., Sutton, A., Solomon, M.J. Cell (1996) [Pubmed]
  23. Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor. Franzén, P., ten Dijke, P., Ichijo, H., Yamashita, H., Schulz, P., Heldin, C.H., Miyazono, K. Cell (1993) [Pubmed]
  24. Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4. Wu, J.Y., Ribar, T.J., Cummings, D.E., Burton, K.A., McKnight, G.S., Means, A.R. Nat. Genet. (2000) [Pubmed]
  25. Mitosis-specific phosphorylation of p60c-src by p34cdc2-associated protein kinase. Morgan, D.O., Kaplan, J.M., Bishop, J.M., Varmus, H.E. Cell (1989) [Pubmed]
  26. Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cox, J.S., Shamu, C.E., Walter, P. Cell (1993) [Pubmed]
  27. Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction. Ozaki, K., Ohnishi, Y., Iida, A., Sekine, A., Yamada, R., Tsunoda, T., Sato, H., Sato, H., Hori, M., Nakamura, Y., Tanaka, T. Nat. Genet. (2002) [Pubmed]
  28. Assembly of the mitochondrial membrane system: sequences of yeast mitochondrial valine and an unusual threonine tRNA gene. Li, M., Tzagoloff, A. Cell (1979) [Pubmed]
  29. Phospholipase D: enzymology, mechanisms of regulation, and function. Exton, J.H. Physiol. Rev. (1997) [Pubmed]
  30. Constitutively activated receptors for parathyroid hormone and parathyroid hormone-related peptide in Jansen's metaphyseal chondrodysplasia. Schipani, E., Langman, C.B., Parfitt, A.M., Jensen, G.S., Kikuchi, S., Kooh, S.W., Cole, W.G., Jüppner, H. N. Engl. J. Med. (1996) [Pubmed]
  31. The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain. Elia, A.E., Rellos, P., Haire, L.F., Chao, J.W., Ivins, F.J., Hoepker, K., Mohammad, D., Cantley, L.C., Smerdon, S.J., Yaffe, M.B. Cell (2003) [Pubmed]
  32. A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase. Malek, N.P., Sundberg, H., McGrew, S., Nakayama, K., Kyriakides, T.R., Roberts, J.M., Kyriakidis, T.R. Nature (2001) [Pubmed]
  33. Structure of 20S proteasome from yeast at 2.4 A resolution. Groll, M., Ditzel, L., Löwe, J., Stock, D., Bochtler, M., Bartunik, H.D., Huber, R. Nature (1997) [Pubmed]
  34. Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase. Lin, H.Y., Wang, X.F., Ng-Eaton, E., Weinberg, R.A., Lodish, H.F. Cell (1992) [Pubmed]
  35. A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. Fisher, R.P., Morgan, D.O. Cell (1994) [Pubmed]
  36. Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor. Penton, A., Chen, Y., Staehling-Hampton, K., Wrana, J.L., Attisano, L., Szidonya, J., Cassill, J.A., Massagué, J., Hoffmann, F.M. Cell (1994) [Pubmed]
  37. BAK1, an Arabidopsis LRR receptor-like protein kinase, interacts with BRI1 and modulates brassinosteroid signaling. Li, J., Wen, J., Lease, K.A., Doke, J.T., Tax, F.E., Walker, J.C. Cell (2002) [Pubmed]
  38. Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Gille, H., Sharrocks, A.D., Shaw, P.E. Nature (1992) [Pubmed]
  39. Control of calcium oscillations by phosphorylation of metabotropic glutamate receptors. Kawabata, S., Tsutsumi, R., Kohara, A., Yamaguchi, T., Nakanishi, S., Okada, M. Nature (1996) [Pubmed]
  40. Analysis of CD36 binding domains: ligand specificity controlled by dephosphorylation of an ectodomain. Asch, A.S., Liu, I., Briccetti, F.M., Barnwell, J.W., Kwakye-Berko, F., Dokun, A., Goldberger, J., Pernambuco, M. Science (1993) [Pubmed]
  41. Cloning and characterization of the cDNA coding for a polymyositis-scleroderma overlap syndrome-related nucleolar 100-kD protein. Blüthner, M., Bautz, F.A. J. Exp. Med. (1992) [Pubmed]
 
WikiGenes - Universities