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Gene Review

FVE  -  WD-40 repeat-containing protein MSI4

Arabidopsis thaliana

Synonyms: ACG1, ATMSI4, F3P11.12, F3P11_12, MSI4, ...
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High impact information on FVE

  • We conclude that FVE participates in a protein complex repressing FLC transcription through a histone deacetylation mechanism [1].
  • Regulation of flowering time by FVE, a retinoblastoma-associated protein [1].
  • BrdU patterns in wild-type plants were correlated with the expression profiles of both several cell cycle genes involved in the control of the G(1)/S transition and cell cycle-related repressor genes, MSI4 and MSI5, encoding WD-repeat proteins [2].

Other interactions of FVE

  • We also showed that plants sense intermittent cold stress through FVE and delay flowering with increasing expression of FLC [3].

Analytical, diagnostic and therapeutic context of FVE

  • By metal affinity chromatography, zinc blotting and atomic absorption analysis, we demonstrate that purified recombinant RbAp48 and AtMSI4 proteins bind 3-4 metal ions per molecule of protein [4].


  1. Regulation of flowering time by FVE, a retinoblastoma-associated protein. Ausín, I., Alonso-Blanco, C., Jarillo, J.A., Ruiz-García, L., Martínez-Zapater, J.M. Nat. Genet. (2004) [Pubmed]
  2. High-resolution boundary analysis during Arabidopsis thaliana flower development. Breuil-Broyer, S., Morel, P., de Almeida-Engler, J., Coustham, V., Negrutiu, I., Trehin, C. Plant J. (2004) [Pubmed]
  3. A genetic link between cold responses and flowering time through FVE in Arabidopsis thaliana. Kim, H.J., Hyun, Y., Park, J.Y., Park, M.J., Park, M.K., Kim, M.D., Kim, H.J., Lee, M.H., Moon, J., Lee, I., Kim, J. Nat. Genet. (2004) [Pubmed]
  4. AtMSI4 and RbAp48 WD-40 repeat proteins bind metal ions. Kenzior, A.L., Folk, W.R. FEBS Lett. (1998) [Pubmed]
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