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Gene Review:

CABLES2 - Cdk5 and Abl enzyme substrate 2

Homo sapiens

Synonyms: C20orf150, CDK5 and ABL1 enzyme substrate 2, Ik3-2, Interactor with CDK3 2, dJ908M14.2, ...

Matsuoka, M. et al., Sato, H. et al.

Matsuoka, Sudo, Tsuji, Sato, Kurita, Suzuki, Nishimoto, Ogata,

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High impact information on CABLES2

In contrast, ik3-2-induced p53-independent apoptosis is mediated through ik3-2-N [1].
Both the highly conserved C-terminal cyclin box-homologous domain (ik3-2-C) and the N-terminal region consisting of 70 amino acids (ik3-2-N) are responsible for ik3-2-mediated enhancement of p53-induced apoptosis [1].
Analysis of amino acid sequence indicated that ik3-2 has the C-terminal cyclin-box-like region highly homologous to that of ik3-1 (identity in amino acids: 78%) [2].

Analytical, diagnostic and therapeutic context of CABLES2

Northern blot analysis indicated that ik3-2 is expressed ubiquitously all over tissues [2].

References

ik3-2, a relative to ik3-1/Cables, is involved in both p53-mediated and p53-independent apoptotic pathways. Matsuoka, M., Sudo, H., Tsuji, K., Sato, H., Kurita, M., Suzuki, H., Nishimoto, I., Ogata, E. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl. Sato, H., Nishimoto, I., Matsuoka, M. Biochim. Biophys. Acta (2002) [Pubmed]

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CABLES2	Bos taurus
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cables2a	Danio rerio
cables2b	Danio rerio
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cables2	Xenopus (Silurana) tropicalis

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