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Gene Review

LGALS7  -  lectin, galactoside-binding, soluble, 7

Homo sapiens

Synonyms: GAL7, LGALS7A, PIG1, TP53I1
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Disease relevance of LGALS7

  • Here, we provide evidence indicating that galectin-7 functions as an important molecule in the dissemination of lymphoma cells in vivo [1].
  • For example, up-regulation of galectin-7 is associated with rat mammary carcinomas and with progression to T-cell malignancy [1].
  • We also found that inhibition of galectin-7 in aggressive lymphoma cells correlated with a decreased invasion of tumor cells in target organs and a reduced expression of matrix metalloproteinase-9, a gene associated with a poor prognosis in non-Hodgkin's lymphoma [1].
  • Galectin-7 is a beta-galactoside binding protein specifically expressed in stratified epithelia and notably in epidermis, but barely detectable in epidermal tumors and absent from squamous carcinoma cell lines [2].
  • In serum-supplemented proliferation assays, galectin-7 reduced neuroblastoma cell growth without the appearance of features characteristic for classical apoptosis [3].

High impact information on LGALS7


Chemical compound and disease context of LGALS7


Biological context of LGALS7


Anatomical context of LGALS7


Associations of LGALS7 with chemical compounds


Physical interactions of LGALS7

  • The p53-induced apoptosis was abrogated by NS5A and the inhibition effect correlates well with the binding ability of NS5A to p53 [22].
  • The ability of ATF3 to stabilize p53-induced pathways thus represents a means of effectively countering DNA damage caused by environmental insult the latter leading to oncogene activation and ultimately malignant transformation [23].

Regulatory relationships of LGALS7


Other interactions of LGALS7


Analytical, diagnostic and therapeutic context of LGALS7


  1. Galectin-7 in lymphoma: elevated expression in human lymphoid malignancies and decreased lymphoma dissemination by antisense strategies in experimental model. Demers, M., Biron-Pain, K., Hébert, J., Lamarre, A., Magnaldo, T., St-Pierre, Y. Cancer Res. (2007) [Pubmed]
  2. Galectin-7 overexpression is associated with the apoptotic process in UVB-induced sunburn keratinocytes. Bernerd, F., Sarasin, A., Magnaldo, T. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  3. Homodimeric galectin-7 (p53-induced gene 1) is a negative growth regulator for human neuroblastoma cells. Kopitz, J., André, S., von Reitzenstein, C., Versluis, K., Kaltner, H., Pieters, R.J., Wasano, K., Kuwabara, I., Liu, F.T., Cantz, M., Heck, A.J., Gabius, H.J. Oncogene (2003) [Pubmed]
  4. TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Bensaad, K., Tsuruta, A., Selak, M.A., Vidal, M.N., Nakano, K., Bartrons, R., Gottlieb, E., Vousden, K.H. Cell (2006) [Pubmed]
  5. DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Crighton, D., Wilkinson, S., O'Prey, J., Syed, N., Smith, P., Harrison, P.R., Gasco, M., Garrone, O., Crook, T., Ryan, K.M. Cell (2006) [Pubmed]
  6. The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation. Beuvink, I., Boulay, A., Fumagalli, S., Zilbermann, F., Ruetz, S., O'Reilly, T., Natt, F., Hall, J., Lane, H.A., Thomas, G. Cell (2005) [Pubmed]
  7. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Oda, E., Ohki, R., Murasawa, H., Nemoto, J., Shibue, T., Yamashita, T., Tokino, T., Taniguchi, T., Tanaka, N. Science (2000) [Pubmed]
  8. Cooperative effects of genes controlling the G(2)/M checkpoint. Chan, T.A., Hwang, P.M., Hermeking, H., Kinzler, K.W., Vogelstein, B. Genes Dev. (2000) [Pubmed]
  9. Gene regulation by temperature-sensitive p53 mutants: identification of p53 response genes. Buckbinder, L., Talbott, R., Seizinger, B.R., Kley, N. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  10. Stress signals utilize multiple pathways to stabilize p53. Ashcroft, M., Taya, Y., Vousden, K.H. Mol. Cell. Biol. (2000) [Pubmed]
  11. 5-aza-2'-deoxycytidine upregulates caspase-9 expression cooperating with p53-induced apoptosis in human lung cancer cells. Gomyo, Y., Sasaki, J., Branch, C., Roth, J.A., Mukhopadhyay, T. Oncogene (2004) [Pubmed]
  12. Inhibition of 6-hydroxydopamine-induced p53 expression and survival of neuroblastoma cells following interaction with astrocytes. Tieu, K., Ashe, P.C., Zuo, D.M., Yu, P.H. Neuroscience (2001) [Pubmed]
  13. Different levels of p53 induced either apoptosis or cell cycle arrest in a doxycycline-regulated hepatocellular carcinoma cell line in vitro. Lai, P.B., Chi, T.Y., Chen, G.G. Apoptosis (2007) [Pubmed]
  14. A model for p53-induced apoptosis. Polyak, K., Xia, Y., Zweier, J.L., Kinzler, K.W., Vogelstein, B. Nature (1997) [Pubmed]
  15. Cloning, expression, and chromosome mapping of human galectin-7. Madsen, P., Rasmussen, H.H., Flint, T., Gromov, P., Kruse, T.A., Honoré, B., Vorum, H., Celis, J.E. J. Biol. Chem. (1995) [Pubmed]
  16. Expression of lysosome-associated membrane protein 1 (Lamp-1) and galectins in human keratinocytes is regulated by differentiation. Sarafian, V., Jans, R., Poumay, Y. Arch. Dermatol. Res. (2006) [Pubmed]
  17. Galectin-7 as a potential mediator of corneal epithelial cell migration. Cao, Z., Said, N., Wu, H.K., Kuwabara, I., Liu, F.T., Panjwani, N. Arch. Ophthalmol. (2003) [Pubmed]
  18. Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release. Kuwabara, I., Kuwabara, Y., Yang, R.Y., Schuler, M., Green, D.R., Zuraw, B.L., Hsu, D.K., Liu, F.T. J. Biol. Chem. (2002) [Pubmed]
  19. Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid. Magnaldo, T., Bernerd, F., Darmon, M. Dev. Biol. (1995) [Pubmed]
  20. Differential gene expression in p53-mediated apoptosis-resistant vs. apoptosis-sensitive tumor cell lines. Maxwell, S.A., Davis, G.E. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  21. A possible role of p73 on the modulation of p53 level through MDM2. Wang, X.Q., Ongkeko, W.M., Lau, A.W., Leung, K.M., Poon, R.Y. Cancer Res. (2001) [Pubmed]
  22. HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis. Lan, K.H., Sheu, M.L., Hwang, S.J., Yen, S.H., Chen, S.Y., Wu, J.C., Wang, Y.J., Kato, N., Omata, M., Chang, F.Y., Lee, S.D. Oncogene (2002) [Pubmed]
  23. ATF3 regulates the stability of p53: a link to cancer. Yan, C., Boyd, D.D. Cell Cycle (2006) [Pubmed]
  24. ASPP proteins specifically stimulate the apoptotic function of p53. Samuels-Lev, Y., O'Connor, D.J., Bergamaschi, D., Trigiante, G., Hsieh, J.K., Zhong, S., Campargue, I., Naumovski, L., Crook, T., Lu, X. Mol. Cell (2001) [Pubmed]
  25. Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage. Hsieh, J.K., Yap, D., O'Connor, D.J., Fogal, V., Fallis, L., Chan, F., Zhong, S., Lu, X. Mol. Cell. Biol. (2002) [Pubmed]
  26. UV but not gamma irradiation accelerates p53-induced apoptosis of teratocarcinoma cells by repressing MDM2 transcription. Zeng, X., Keller, D., Wu, L., Lu, H. Cancer Res. (2000) [Pubmed]
  27. MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts. Gentiletti, F., Mancini, F., D'Angelo, M., Sacchi, A., Pontecorvi, A., Jochemsen, A.G., Moretti, F. Oncogene (2002) [Pubmed]
  28. Analyses of Five gallinacin genes and the Salmonella enterica serovar Enteritidis response in poultry. Hasenstein, J.R., Zhang, G., Lamont, S.J. Infect. Immun. (2006) [Pubmed]
  29. Galectin 7 (p53-induced gene 1): a new prognostic predictor of recurrence and survival in stage IV hypopharyngeal cancer. Saussez, S., Cucu, D.R., Decaestecker, C., Chevalier, D., Kaltner, H., André, S., Wacreniez, A., Toubeau, G., Camby, I., Gabius, H.J., Kiss, R. Ann. Surg. Oncol. (2006) [Pubmed]
  30. Galectin-7, a marker of all types of stratified epithelia. Magnaldo, T., Fowlis, D., Darmon, M. Differentiation (1998) [Pubmed]
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