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Gene Review

GTPBP6  -  GTP binding protein 6 (putative)

Homo sapiens

Synonyms: FLJ20977, PGPL, Pseudoautosomal GTP-binding protein-like
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High impact information on GTPBP6

  • The PGPL gene encodes a protein of 442 amino acids and shows the consensus sequences of a series of motifs of the GTP-binding protein domain [1].
  • We report the cloning of a novel Xp/Yp pseudoautosomal gene called PGPL , and demonstrate that PGPL , like other pseudoautosomal genes, escapes X inactivation and has a functional homologue on the Y chromosome [1].


  1. A novel pseudoautosomal gene encoding a putative GTP-binding protein resides in the vicinity of the Xp/Yp telomere. Gianfrancesco, F., Esposito, T., Montanini, L., Ciccodicola, A., Mumm, S., Mazzarella, R., Rao, E., Giglio, S., Rappold, G., Forabosco, A. Hum. Mol. Genet. (1998) [Pubmed]
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