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Gene Review

ECR1  -  NEDD8-activating enzyme E1 catalytic subunit

Arabidopsis thaliana

Synonyms: E1 C-terminal related 1, T24G5.80, T24G5_80
 
 
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High impact information on ECR1

  • Extracts from mutant seedlings lacking AXR1 did not promote formation of the RUB-ECR1 thiolester, indicating that AXR1 is the major activity in this tissue [1].
 

Biological context of ECR1

  • The expression of AXR1 and ECR1 is restricted to zones of active cell division and cell elongation, consistent with their role in growth regulation [2].
 

Other interactions of ECR1

  • The first step in the pathway is RUB activation by a bipartite enzyme composed of the AXR1 and ECR1 proteins [3].

References

  1. The ubiquitin-related protein RUB1 and auxin response in Arabidopsis. Pozo, J.C., Timpte, C., Tan, S., Callis, J., Estelle, M. Science (1998) [Pubmed]
  2. AXR1-ECR1-dependent conjugation of RUB1 to the Arabidopsis Cullin AtCUL1 is required for auxin response. del Pozo, J.C., Dharmasiri, S., Hellmann, H., Walker, L., Gray, W.M., Estelle, M. Plant Cell (2002) [Pubmed]
  3. The Arabidopsis cullin AtCUL1 is modified by the ubiquitin-related protein RUB1. del Pozo, J.C., Estelle, M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
 
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