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Gene Review

UBA3  -  ubiquitin-like modifier activating enzyme 3

Homo sapiens

Synonyms: NAE2, NEDD8-activating enzyme E1 catalytic subunit, NEDD8-activating enzyme E1C, UBE1C, Ubiquitin-activating enzyme 3, ...
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High impact information on UBE1C

  • We show that expression of APP-BP1 in ts41 cells drives the cell cycle through the S-M checkpoint and that this function requires both hUba3 and hUbc12 [1].
  • These data explain why the Ubc12-UBA3 interaction is unique to the NEDD8 pathway [2].


  1. The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons. Chen, Y., McPhie, D.L., Hirschberg, J., Neve, R.L. J. Biol. Chem. (2000) [Pubmed]
  2. A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8. Huang, D.T., Miller, D.W., Mathew, R., Cassell, R., Holton, J.M., Roussel, M.F., Schulman, B.A. Nat. Struct. Mol. Biol. (2004) [Pubmed]
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