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Gene Review

BIO1  -  bifunctional dethiobiotin synthetase/7,8...

Arabidopsis thaliana

Synonyms: MUA2.17, MUA2_17, biotin auxotroph 1
 
 
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Disease relevance of BIO1

 

High impact information on BIO1

  • In response to the bio1-associated depletion of biotin, the normally biotinylated A-subunit of methylcrotonyl-CoA carboxylase (MCCase) accumulates in its inactive apo-form, and both MCCase subunits hyperaccumulate [2].
  • The Arabidopsis thaliana biotin auxotroph biol was rendered prototrophic by transformation with a chimeric transgene containing the Escherichia coli bio A gene driven by a constitutive promoter [1].
  • These findings demonstrate that bio1/bio1 mutant plants are defective in the gene encoding 7,8-diaminopelargonic acid aminotransferase [1].
  • This strategy was tested by demonstrating that the bio1 locus of Arabidopsis is within 0.5 cM of an existing RFLP marker [3].

References

  1. Complementation of an Arabidopsis thaliana biotin auxotroph with an Escherichia coli biotin biosynthetic gene. Patton, D.A., Volrath, S., Ward, E.R. Mol. Gen. Genet. (1996) [Pubmed]
  2. The role of biotin in regulating 3-methylcrotonyl-coenzyme a carboxylase expression in Arabidopsis. Che, P., Weaver, L.M., Wurtele, E.S., Nikolau, B.J. Plant Physiol. (2003) [Pubmed]
  3. Mapping genes essential for embryo development in Arabidopsis thaliana. Patton, D.A., Franzmann, L.H., Meinke, D.W. Mol. Gen. Genet. (1991) [Pubmed]
 
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