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Gene Review:

GSA1 - glutamate-1-semialdehyde-2,1-aminomutase

Arabidopsis thaliana

Synonyms: "glutamate-1-semialdehyde-2,1-aminomutase", 1-AMINOMUTASE, 1-aminomutase, GLUTAMATE-1-SEMIALDEHYDE-2, GSA-AM, ...

Ilag, L.L. et al., Kumar, A.M. et al.

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High impact information on GSA1

Each gene contains two short introns (149 and 241 nucleotides for HEMA, 153 and 86 nucleotides for GSA1) [1].
The GSA1 gene encodes a 50-kD protein whose deduced amino acid sequence shows extensive homology (55 to 78% identity) with glutamate 1-semialdehyde 2,1-aminomutase proteins from other species [1].
The second enzyme, glutamate 1-semialdehyde 2,1-aminomutase, converts glutamate 1-semialdehyde to ALA [1].
In the first step, glutamyl-tRNA reductase (GluTR), converts glutamate of glutamyl-tRNA to glutamate 1-semialdehyde (GSA) which is rearranged to ALA by glutamate 1-semialdehyde-2,1-aminomutase (GSA-A) in the second step [2].

References

Light regulation of chlorophyll biosynthesis at the level of 5-aminolevulinate formation in Arabidopsis. Ilag, L.L., Kumar, A.M., Söll, D. Plant Cell (1994) [Pubmed]
A second and differentially expressed glutamyl-tRNA reductase gene from Arabidopsis thaliana. Kumar, A.M., Csankovszki, G., Söll, D. Plant Mol. Biol. (1996) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

GSA2	Arabidopsis thaliana
NCU11422	Neurospora crassa OR74A
Os08g0532200	Oryza sativa Japonica Group
SPCC417.11c	Schizosaccharomyces pombe 972h-

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