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Gene Review:

CIP8 - COP1-interacting protein 8

Arabidopsis thaliana

Synonyms: COP1-INTERACTING PROTEIN CIP8, MXK3.15, MXK3_15

Torii, K.U. et al., Hardtke, C.S. et al.

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High impact information on CIP8

The allele specific effect of cop1 mutations on the CIP8 protein accumulation in seedlings indicates that its stability in vivo is dependent on the COP1 protein [1].
This protein, designated COP1 Interacting Protein 8 (CIP8), is encoded by a single copy gene and localized to cytosol in a transient assay [1].
Here we show that CIP8 promotes ubiquitin attachment to HY5 in E2-dependent fashion in vitro [2].
CIP8 exhibits a strong interaction with the E2 enzyme AtUBC8 through its N-terminal domain [2].

Other interactions of CIP8

The RING domain of CIP8 is required but is not sufficient for ubiquitin ligase activity [2].

References

The RING finger motif of photomorphogenic repressor COP1 specifically interacts with the RING-H2 motif of a novel Arabidopsis protein. Torii, K.U., Stoop-Myer, C.D., Okamoto, H., Coleman, J.E., Matsui, M., Deng, X.W. J. Biol. Chem. (1999) [Pubmed]
Biochemical evidence for ubiquitin ligase activity of the Arabidopsis COP1 interacting protein 8 (CIP8). Hardtke, C.S., Okamoto, H., Stoop-Myer, C., Deng, X.W. Plant J. (2002) [Pubmed]

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