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Gene Review

CIP8  -  COP1-interacting protein 8

Arabidopsis thaliana

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High impact information on CIP8

  • The allele specific effect of cop1 mutations on the CIP8 protein accumulation in seedlings indicates that its stability in vivo is dependent on the COP1 protein [1].
  • This protein, designated COP1 Interacting Protein 8 (CIP8), is encoded by a single copy gene and localized to cytosol in a transient assay [1].
  • Here we show that CIP8 promotes ubiquitin attachment to HY5 in E2-dependent fashion in vitro [2].
  • CIP8 exhibits a strong interaction with the E2 enzyme AtUBC8 through its N-terminal domain [2].

Other interactions of CIP8

  • The RING domain of CIP8 is required but is not sufficient for ubiquitin ligase activity [2].


  1. The RING finger motif of photomorphogenic repressor COP1 specifically interacts with the RING-H2 motif of a novel Arabidopsis protein. Torii, K.U., Stoop-Myer, C.D., Okamoto, H., Coleman, J.E., Matsui, M., Deng, X.W. J. Biol. Chem. (1999) [Pubmed]
  2. Biochemical evidence for ubiquitin ligase activity of the Arabidopsis COP1 interacting protein 8 (CIP8). Hardtke, C.S., Okamoto, H., Stoop-Myer, C., Deng, X.W. Plant J. (2002) [Pubmed]
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