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Gene Review

Kremen1  -  kringle containing transmembrane protein 1

Mus musculus

Synonyms: AV002070, Dickkopf receptor, Kremen, Kremen protein 1, Kringle domain-containing transmembrane protein 1, ...
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High impact information on Kremen1

  • We have investigated the role of Krm1 and Krm2 during early Xenopus embryogenesis [1].
  • In this study we show that Dkk1, -2, and -3 are expressed distally in the epithelium, while Kremen1, the needed co-receptor, is expressed throughout the epithelium of the developing lung [2].
  • Taken together, this study revealed a new role for Krm1 in proper development of thymic epithelium [3].


  1. Kremen proteins interact with Dickkopf1 to regulate anteroposterior CNS patterning. Davidson, G., Mao, B., del Barco Barrantes, I., Niehrs, C. Development (2002) [Pubmed]
  2. Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung. De Langhe, S.P., Sala, F.G., Del Moral, P.M., Fairbanks, T.J., Yamada, K.M., Warburton, D., Burns, R.C., Bellusci, S. Dev. Biol. (2005) [Pubmed]
  3. The Wnt signaling antagonist Kremen1 is required for development of thymic architecture. Osada, M., Ito, E., Fermin, H.A., Vazquez-Cintron, E., Venkatesh, T., Friedel, R.H., Pezzano, M. Clin. Dev. Immunol. (2006) [Pubmed]
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