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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ANNAT1  -  annexin 1

Arabidopsis thaliana

Synonyms: ANN1, ANNEXIN, ANNEXIN A1, ATOXY5, AtANN1, ...
 
 
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Disease relevance of ANNAT1

  • We have previously shown that an annexin-like protein from Arabidopsis thaliana, termed Oxy5, can replace the obligatory role of OxyR in E. coli [1].
 

High impact information on ANNAT1

 

Associations of ANNAT1 with chemical compounds

  • S-glutathionylation of AnnAt1 occurs in planta after abscisic acid treatment, which suggests that this modification could be important in regulating the cellular function of AnnAt1 during stress responses [2].
 

Biological context of ANNAT1

  • Recently we have cloned and characterized a novel, oxidative stress-induced Arabidopsis thaliana gene (oxy5), and showed that expression of oxy5 protects bacterial cells from death caused by oxidative stress [3].
 

Analytical, diagnostic and therapeutic context of ANNAT1

  • Taken together, the results demonstrate an antioxidant role for plant oxy5 gene in mammalian cells, which can be potentially utilized in gene therapy programs aimed at reducing the deleterious effects of ROS [1].

References

  1. Oxy5, a novel protein from Arabidopsis thaliana, protects mammalian cells from oxidative stress. Kush, A., Sabapathy, K. Int. J. Biochem. Cell Biol. (2001) [Pubmed]
  2. The role of annexin 1 in drought stress in Arabidopsis. Konopka-Postupolska, D., Clark, G., Goch, G., Debski, J., Floras, K., Cantero, A., Fijolek, B., Roux, S., Hennig, J. Plant Physiol. (2009) [Pubmed]
  3. A novel Arabidopsis thaliana protein protects tumor cells from tumor necrosis factor-induced apoptosis. Jänicke, R.U., Porter, A.G., Kush, A. Biochim. Biophys. Acta (1998) [Pubmed]
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