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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

RPF2  -  ribosome production factor 2 homolog (S....

Homo sapiens

Synonyms: BXDC1, Brix domain-containing protein 1, FLJ21087, Ribosome biogenesis protein RPF2 homolog, Ribosome production factor 2 homolog, ...
 
 
 
 
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High impact information on BXDC1

  • The amino acid sequence of Rpf2p is highly conserved in eukaryotes from yeast to human [1].
  • Northern, methionine pulse-chase, and sucrose density gradient ultracentrifugation analyses reveal that the depletion of Rpf2p results in a delayed processing of pre-rRNA, a decrease of mature 25 S rRNA, and a shortage of 60 S subunits [1].

References

  1. Rpf2p, an evolutionarily conserved protein, interacts with ribosomal protein L11 and is essential for the processing of 27 SB Pre-rRNA to 25 S rRNA and the 60 S ribosomal subunit assembly in Saccharomyces cerevisiae. Morita, D., Miyoshi, K., Matsui, Y., Toh-E, A., Shinkawa, H., Miyakawa, T., Mizuta, K. J. Biol. Chem. (2002) [Pubmed]
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