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Gene Review

FLYWCH1  -  FLYWCH-type zinc finger 1

Homo sapiens

Synonyms: DKFZp761A132, FLYWCH-type zinc finger-containing protein 1, KIAA1552
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High impact information on FLYWCH1

  • Caenorhabditis elegans PEB-1 is a novel protein containing a DNA-binding domain in its N terminus, which includes a Cys/His-rich FLYWCH motif also found in Drosophila Mod(mdg4) proteins, and a large C-terminal domain of unknown function [1].
  • Su(Kpn) is a unique protein with four N-terminal FLYWCH zinc-finger domains, an acidic domain and a C-terminal glutathione S-transferase (GST) domain [2].


  1. DNA binding and in vivo function of C.elegans PEB-1 require a conserved FLYWCH motif. Beaster-Jones, L., Okkema, P.G. J. Mol. Biol. (2004) [Pubmed]
  2. The Suppressor of Killer of prune, a unique glutathione S-transferase. Provost, E., Shearn, A. J. Bioenerg. Biomembr. (2006) [Pubmed]
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