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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SYT3  -  synaptotagmin III

Homo sapiens

Synonyms: Synaptotagmin III, Synaptotagmin-3, SytIII
 
 
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High impact information on SYT3

  • Structures of the SNARE complex, synaptotagmin III, nSec1, domains of the NSF chaperone and its adaptor SNAP, and Rab3 and some of its effectors provide the framework for developing molecular models of vesicle fusion and for designing experiments to test these models [1].
  • Impaired SYT3 function blocked CXCR4 recycling and thus led to reduced surface levels of CXCR4 [2].
  • Amongst synaptotagmins 1-11, we found synaptotagmin 3 (SYT3) to be the only one that is expressed in T cells [2].
 

Anatomical context of SYT3

  • Surprisingly, we found that little or no SYT3 is present near the plasma membrane but that it is mainly localized in multivesicular bodies, which also contained much of the CXCR4 [2].
 

Associations of SYT3 with chemical compounds

  • CXCR4-triggered migration was inhibited by antisense synaptotagmin 3 mRNA and by the isolated C2B domain, known to impair oligomerization of all synaptotagmins, but not by a C2B mutant that binds Ca(2+) but does not block oligomerization [2].

References

  1. Structure of proteins involved in synaptic vesicle fusion in neurons. Brunger, A.T. Annual review of biophysics and biomolecular structure. (2001) [Pubmed]
  2. Synaptotagmin 3 deficiency in T cells impairs recycling of the chemokine receptor CXCR4 and thereby inhibits CXCL12 chemokine-induced migration. Masztalerz, A., Zeelenberg, I.S., Wijnands, Y.M., de Bruijn, R., Drager, A.M., Janssen, H., Roos, E. J. Cell. Sci. (2007) [Pubmed]
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