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Gene Review

ARFGAP2  -  ADP-ribosylation factor GTPase activating...

Homo sapiens

Synonyms: ADP-ribosylation factor GTPase-activating protein 2, ARF GAP 2, FLJ14576, GTPase-activating protein ZNF289, IRZ, ...
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Psychiatry related information on ZNF289

  • The MPB, SPB, and IRZ display cytoskeletal pathology in stage I and the LPB in stage II, whereby bothstages correspond to the preclinical phase of Alzheimer's disease (AD) [1].

High impact information on ZNF289

  • We examined the MPB, LPB, SPP and IRZ in 27 autopsy cases and classified the cortical Alzheimer-related cytoskeletal anomalies according to an established staging system (neurofibrillary tangle/neuropil threads [NFT/NT] stages I-VI) [1].
  • The nuclei of the pontine parabrachial region (medial parabrachial nucleus, MPB; lateral parabrachial nucleus, LPB; subpeduncular nucleus, SPP) together with the intermediate zone of the medullary reticular formation (IRZ) are pivotal relay stations within central autonomic regulatory feedback systems [1].


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