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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Neuropil

 
 
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Disease relevance of Neuropil

 

Psychiatry related information on Neuropil

 

High impact information on Neuropil

  • The application of an antagonist of ionotropic gamma-aminobutyric acid (GABA) receptors to the first olfactory relay neuropil selectively blocked the fast inhibitory synapse between local and projection neurons [10].
  • Autoradiograms prepared from adult rat brains demonstrate that nerve cells and neuropil in different brain regions selectively concentrate and retain intravenously administered triiodothyronine, by mechanisms susceptible to saturation with excess triiodothyronine [11].
  • We used patch-clamp recordings, electron microscopic immunogold localization of AMPARs, partial three-dimensional reconstruction of the neuropil and numerical simulations of glutamate diffusion and AMPAR activation to examine the factors underlying the developmental speeding of miniature EPSCs in mouse cerebellar granule cells [12].
  • Neurofibrillary tangle-bearing neurons and neuropil threads contained NOS2 in brains from each of 11 AD patients ranging in age from 47 to 81 years [13].
  • The cyclic AMP phosphodiesterase encoded by the Drosophila dunce gene is concentrated in the mushroom body neuropil [14].
 

Chemical compound and disease context of Neuropil

 

Biological context of Neuropil

 

Anatomical context of Neuropil

 

Associations of Neuropil with chemical compounds

  • Furthermore, most labeled spines did not receive synapses with dopaminergic features, suggesting that many D1 receptors are at extrasynaptic sites, possibly receiving dopamine via diffusion in the neuropil [30].
  • Odorants evoked patterns of discrete Ca(2+) signals throughout the neuropil of a glomerulus [31].
  • We also show that oral treatment of caged bees with pilocarpine, a muscarinic agonist, induced an increase in the volume of the neuropil similar to that seen after a week of foraging experience [32].
  • Colloidal gold staining under the electron microscope was associated with 80- to 100-nm vesicles of average electron density, widely dispersed in the neuropil, with usually one and no more than four vesicles in individual sectioned neuronal processes [33].
  • After injections of estradiol benzoate or oil vehicle to the hosts for 20 successive days, the grafts were processed for semiquantitative electron microscopic study to examine synaptic density in the neuropil [34].
 

Gene context of Neuropil

  • Mutations of ey completely disrupted the MB neuropils, and a null mutation of dac resulted in marked disruption and aberrant axonal projections [35].
  • By IF, Cx36 labeling was widely distributed in neuropil, including along dendritic processes and within neuronal somata [36].
  • Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse [37].
  • Immunocytochemical studies of mouse brain reveal that PS1 protein accumulates in a variety of neuronal populations with enrichment in somatodendritic and neuropil compartments [38].
  • In contrast, when delivered intraseptally, the same dose of BDNF exhibited a widespread diffusion within the surrounding neuropil and retrograde labeling of neurons in the medial septum and the vertical limb of the diagonal band [39].
 

Analytical, diagnostic and therapeutic context of Neuropil

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