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Gene Review

Grb7  -  growth factor receptor bound protein 7

Rattus norvegicus

Synonyms: Epidermal growth factor receptor GRB-7, GRB7 adapter protein, Growth factor receptor-bound protein 7
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High impact information on Grb7

  • Grb7 binds the activated tyrosine kinase loop of the insulin receptors [1].
  • These differences should be a determinant of the specificity of the receptor tyrosine kinase-Grbs binding, and thus of the implication of Grb7/10/14 in signal transduction [1].
  • Two domains of Grb7 are implicated in the insulin receptor binding: the SH2 domain and the PIR (phosphotyrosine interacting region) [1].


  1. Evidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2. Kasus-Jacobi, A., Béréziat, V., Perdereau, D., Girard, J., Burnol, A.F. Oncogene (2000) [Pubmed]
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