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Gene Review

Grb7  -  growth factor receptor bound protein 7

Mus musculus

Synonyms: Epidermal growth factor receptor GRB-7, GRB7 adapter protein, Growth factor receptor-bound protein 7
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High impact information on Grb7

  • Grb10 is highly related to Grb7, an SH2 domain protein that we have previously identified [1].
  • Grb10 maps to mouse chromosome 11 very close to the EGF-Receptor which is remarkably similar to Grb7 that maps near the EGF-Receptor related HER2 receptor [1].
  • The growth factor receptor binding gene Grb7, in contrast, was strongly reduced in its expression in most of the M16 + FCS fetuses [2].
  • B47 consisted of 615 base pairs and had about 85% homology with the corresponding sequence of mouse Grb-7 [3].
  • By investigating and correlating Grb7 gene expression with that reported for Grb7-binding receptors, we provide clues to Grb7 function(s) [4].

Anatomical context of Grb7

  • In situ hybridization at E14 demonstrated the following cellular pattern of localization: Grb7 mRNA in metanephric epithelia of mesenchymal and ureteric bud origin; no expression in the undifferentiated mesenchyme; and little expression in podocyte-destined cells or primitive glomeruli [4].

Associations of Grb7 with chemical compounds

  • Grb7, a signaling protein whose physiological function is unknown, binds receptor tyrosine kinases important for normal kidney development [4].
  • Thus Grb7 may have a basic function in growth factor signaling in terminally differentiated epithelia along the nephron and in developing epithelia in the kidney, lung, and gut [4].

Analytical, diagnostic and therapeutic context of Grb7

  • RT-PCR and immunoblot were used to demonstrate Grb7 gene and protein expression in the mature kidney [4].


  1. The cloning of Grb10 reveals a new family of SH2 domain proteins. Ooi, J., Yajnik, V., Immanuel, D., Gordon, M., Moskow, J.J., Buchberg, A.M., Margolis, B. Oncogene (1995) [Pubmed]
  2. Culture of preimplantation mouse embryos affects fetal development and the expression of imprinted genes. Khosla, S., Dean, W., Brown, D., Reik, W., Feil, R. Biol. Reprod. (2001) [Pubmed]
  3. Molecular cloning of human GRB-7 co-amplified with CAB1 and c-ERBB-2 in primary gastric cancer. Kishi, T., Sasaki, H., Akiyama, N., Ishizuka, T., Sakamoto, H., Aizawa, S., Sugimura, T., Terada, M. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  4. Expression of Grb7 growth factor receptor signaling protein in kidney development and in adult kidney. Leavey, S.F., Arend, L.J., Dare, H., Dressler, G.R., Briggs, J.P., Margolis, B.L. Am. J. Physiol. (1998) [Pubmed]
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