High impact information on Grb7

• Grb10 is highly related to Grb7, an SH2 domain protein that we have previously identified [1].
• Grb10 maps to mouse chromosome 11 very close to the EGF-Receptor which is remarkably similar to Grb7 that maps near the EGF-Receptor related HER2 receptor [1].
• The growth factor receptor binding gene Grb7, in contrast, was strongly reduced in its expression in most of the M16 + FCS fetuses [2].
• B47 consisted of 615 base pairs and had about 85% homology with the corresponding sequence of mouse Grb-7 [3].
• By investigating and correlating Grb7 gene expression with that reported for Grb7-binding receptors, we provide clues to Grb7 function(s) [4].

Anatomical context of Grb7

• In situ hybridization at E14 demonstrated the following cellular pattern of localization: Grb7 mRNA in metanephric epithelia of mesenchymal and ureteric bud origin; no expression in the undifferentiated mesenchyme; and little expression in podocyte-destined cells or primitive glomeruli [4].

Associations of Grb7 with chemical compounds

• Grb7, a signaling protein whose physiological function is unknown, binds receptor tyrosine kinases important for normal kidney development [4].
• Thus Grb7 may have a basic function in growth factor signaling in terminally differentiated epithelia along the nephron and in developing epithelia in the kidney, lung, and gut [4].

Analytical, diagnostic and therapeutic context of Grb7

• RT-PCR and immunoblot were used to demonstrate Grb7 gene and protein expression in the mature kidney [4].

References