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Gene Review

SPPL2A  -  signal peptide peptidase like 2A

Homo sapiens

Synonyms: IMP-3, IMP3, Intramembrane protease 3, PSEC0147, PSL2, ...
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High impact information on SPPL2A

  • Previously, we isolated a Vk gene (Humkv325) from a human placenta that encodes RF light chains bearing the PSL2 and PSL3 CRI markers [1].
  • Therefore, a proportion of the polyclonal RF from different autoimmune states may represent somatic variants of this germ-line RF Vk gene which retain the PSL2 sequence as a common element [2].
  • PSL1 can be converted into PSL2 by carboxypeptidase P from Penicillium janthinellum [3].

Biological context of SPPL2A

  • We have determined the V region amino acid sequence and/or serologic markers (kIIIb, PSL2, and PSL3) of 24 IgM monoclonal autoantibodies with specificities of anti-gamma-globulin (RF), anti-I (cold agglutinin), anti-low density lipoprotein and anti-intermediate filaments [4].

Analytical, diagnostic and therapeutic context of SPPL2A

  • In previous experiments in which we used an enzyme-linked immunosorbent assay, we reported that a synthetic peptide (PSL2), corresponding to the second hypervariable region in the kappa light chain of a monoclonal IgM-RF (Sie), induced rabbit antibodies reactive with several RF paraproteins [5].


  1. Isolation and characterization of a light chain variable region gene for human rheumatoid factors. Chen, P.P., Robbins, D.L., Jirik, F.R., Kipps, T.J., Carson, D.A. J. Exp. Med. (1987) [Pubmed]
  2. Expression of three cross-reactive idiotypes on rheumatoid factor autoantibodies from patients with autoimmune diseases and seropositive adults. Fong, S., Chen, P.P., Gilbertson, T.A., Weber, J.R., Fox, R.I., Carson, D.A. J. Immunol. (1986) [Pubmed]
  3. Pea (Pisum sativum L.) seed isolectins 1 and 2 and pea root lectin result from carboxypeptidase-like processing of a single gene product. Hoedemaeker, F.J., Richardson, M., Díaz, C.L., de Pater, B.S., Kijne, J.W. Plant Mol. Biol. (1994) [Pubmed]
  4. Structural and idiotypic characterization of the L chains of human IgM autoantibodies with different specificities. Goñi, F.R., Chen, P.P., McGinnis, D., Arjonilla, M.L., Fernandez, J., Carson, D., Solomon, A., Mendez, E., Frangione, B. J. Immunol. (1989) [Pubmed]
  5. The majority of human monoclonal IgM rheumatoid factors express a "primary structure-dependent" cross-reactive idiotype. Chen, P.P., Goñi, F., Fong, S., Jirik, F., Vaughan, J.H., Frangione, B., Carson, D.A. J. Immunol. (1985) [Pubmed]
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