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Gene Review

MAP4K3  -  mitogen-activated protein kinase kinase...

Homo sapiens

Synonyms: GLK, Germinal center kinase-related protein kinase, MAPK/ERK kinase kinase kinase 3, MAPKKKK3, MEK kinase kinase 3, ...
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High impact information on MAP4K3

  • In addition to synaptic vesicle formation, endophilin-1 complexes with signalling molecules, including cell surface receptors, metalloprotease disintegrins and germinal centre kinase-like kinase (GLK) [1].
  • The GLK (and homologous or analogous motifs) and the eukaryotic porin motifs in the four representative Chordates tend to be in exons that appear to have changed little during the evolution of these metazoans [2].


  1. Endophilin-1: a multifunctional protein. Reutens, A.T., Begley, C.G. Int. J. Biochem. Cell Biol. (2002) [Pubmed]
  2. The evolutionary history of mitochondrial porins. Young, M.J., Bay, D.C., Hausner, G., Court, D.A. BMC Evol. Biol. (2007) [Pubmed]
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