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Gene Review

DEG1  -  pseudouridine synthase DEG1

Saccharomyces cerevisiae S288c

Synonyms: Depressed growth-rate protein DEG1, HRM3, PUS3, YFL001W, tRNA pseudouridine synthase 3, ...
 
 
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Disease relevance of DEG1

 

High impact information on DEG1

  • Here we have analyzed the in vivo effect of deleting genes coding for yeast tRNA-modifying enzymes, namely Pus1p, Pus3p, Pus4p, or Trm4p, on termination readthrough and +1 frameshift events [2].
  • Identification of the pseudouridine residues present (or absent) in selected naturally occurring cytoplasmic and mitochondrial tRNAs from DEG1-disrupted strain points out a common origin of psi 38- and psi 39-synthesizing activity in both of these two cellular compartments [3].
  • In addition, two pseudouridine synthases, PUS3 and PUS4, are important for growth in strains carrying a mutation in tRNA(Arg)(CCG) and are essential when La is deleted in these strains [4].
  • The trans-acting nuclear mutation hrm3-1 specifically reduces HOT1-dependent recombination and prevents cell growth at 37 degrees . The HRM3 gene is identical to DEG1 [5].
  • Pus3p is unique in its ability to modulate frameshifting and readthrough events during translation, and this aspect of its activity may be responsible for HOT1 recombination phenotypes observed in deg1 mutants [5].
 

Associations of DEG1 with chemical compounds

References

  1. A gene tightly linked to CEN6 is important for growth of Saccharomyces cerevisiae. Carbone, M.L., Solinas, M., Sora, S., Panzeri, L. Curr. Genet. (1991) [Pubmed]
  2. Lack of pseudouridine 38/39 in the anticodon arm of yeast cytoplasmic tRNA decreases in vivo recoding efficiency. Lecointe, F., Namy, O., Hatin, I., Simos, G., Rousset, J.P., Grosjean, H. J. Biol. Chem. (2002) [Pubmed]
  3. Characterization of yeast protein Deg1 as pseudouridine synthase (Pus3) catalyzing the formation of psi 38 and psi 39 in tRNA anticodon loop. Lecointe, F., Simos, G., Sauer, A., Hurt, E.C., Motorin, Y., Grosjean, H. J. Biol. Chem. (1998) [Pubmed]
  4. The La protein functions redundantly with tRNA modification enzymes to ensure tRNA structural stability. Copela, L.A., Chakshusmathi, G., Sherrer, R.L., Wolin, S.L. RNA (2006) [Pubmed]
  5. DEG1, encoding the tRNA:pseudouridine synthase Pus3p, impacts HOT1-stimulated recombination in Saccharomyces cerevisiae. Hepfer, C.E., Arnold-Croop, S., Fogell, H., Steudel, K.G., Moon, M., Roff, A., Zaikoski, S., Rickman, A., Komsisky, K., Harbaugh, D.L., Lang, G.I., Keil, R.L. Mol. Genet. Genomics (2005) [Pubmed]
 
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