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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

GCN20  -  putative AAA family ATPase GCN20

Saccharomyces cerevisiae S288c

Synonyms: Protein GCN20, YFR009W
 
 
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High impact information on GCN20

  • We conclude that binding of GCN1-GCN20 to GCN2 is required for its activation by uncharged tRNA [1].
  • We conclude that GCN1 and GCN20 are components of a protein complex that couples the kinase activity of GCN2 to the availability of amino acids [2].
  • The N-terminal 15 to 25% of GCN20, which is critically required for its regulatory function, was found to interact with an internal segment of GCN1 similar in sequence to translation elongation factor 3 (EF3) [3].
 

Biological context of GCN20

  • Consistently, this Gcn(-) phenotype was suppressed by overexpressing GCN2, GCN1-GCN20 or tRNA(His) [1].
  • We describe point mutations in two conserved, noncontiguous segments of GCN1 that lead to reduced polyribosome association by GCN1.GCN20 in living cells without reducing GCN1 expression or its interaction with GCN20 [4].
 

Physical interactions of GCN20

  • In accordance with this conclusion, GCN20 was co-immunoprecipitated from cell extracts with GCN1, another factor required to activate GCN2, and the two proteins interacted in the yeast two-hybrid system [2].

References

  1. Association of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activation. Garcia-Barrio, M., Dong, J., Ufano, S., Hinnebusch, A.G. EMBO J. (2000) [Pubmed]
  2. GCN20, a novel ATP binding cassette protein, and GCN1 reside in a complex that mediates activation of the eIF-2 alpha kinase GCN2 in amino acid-starved cells. Vazquez de Aldana, C.R., Marton, M.J., Hinnebusch, A.G. EMBO J. (1995) [Pubmed]
  3. Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2. Marton, M.J., Vazquez de Aldana, C.R., Qiu, H., Chakraburtty, K., Hinnebusch, A.G. Mol. Cell. Biol. (1997) [Pubmed]
  4. Polyribosome binding by GCN1 is required for full activation of eukaryotic translation initiation factor 2{alpha} kinase GCN2 during amino acid starvation. Sattlegger, E., Hinnebusch, A.G. J. Biol. Chem. (2005) [Pubmed]
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