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Gene Review

GCN20  -  putative AAA family ATPase GCN20

Saccharomyces cerevisiae S288c

Synonyms: Protein GCN20, YFR009W
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High impact information on GCN20

  • We conclude that binding of GCN1-GCN20 to GCN2 is required for its activation by uncharged tRNA [1].
  • We conclude that GCN1 and GCN20 are components of a protein complex that couples the kinase activity of GCN2 to the availability of amino acids [2].
  • The N-terminal 15 to 25% of GCN20, which is critically required for its regulatory function, was found to interact with an internal segment of GCN1 similar in sequence to translation elongation factor 3 (EF3) [3].

Biological context of GCN20

  • Consistently, this Gcn(-) phenotype was suppressed by overexpressing GCN2, GCN1-GCN20 or tRNA(His) [1].
  • We describe point mutations in two conserved, noncontiguous segments of GCN1 that lead to reduced polyribosome association by GCN1.GCN20 in living cells without reducing GCN1 expression or its interaction with GCN20 [4].

Physical interactions of GCN20

  • In accordance with this conclusion, GCN20 was co-immunoprecipitated from cell extracts with GCN1, another factor required to activate GCN2, and the two proteins interacted in the yeast two-hybrid system [2].


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