Gene Review:
GCN2 - Gcn2p
Saccharomyces cerevisiae S288c
Synonyms:
AAS1, AAS102, NDR2, Serine/threonine-protein kinase GCN2, YDR283C
- The protein kinase Gcn2p mediates sodium toxicity in yeast. Goossens, A., Dever, T.E., Pascual-Ahuir, A., Serrano, R. J. Biol. Chem. (2001)
- Expression of vaccinia virus K3L protein in yeast inhibits eukaryotic initiation factor-2 kinase GCN2 and the general amino acid control pathway. Qian, W., Zhu, S., Sobolev, A.Y., Wek, R.C. J. Biol. Chem. (1996)
- The GCN2 eIF2alpha Kinase Regulates Fatty-Acid Homeostasis in the Liver during Deprivation of an Essential Amino Acid. Guo, F., Cavener, D.R. Cell Metab. (2007)
- Nutrient-regulated protein kinases in budding yeast. Wilson, W.A., Roach, P.J. Cell (2002)
- Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast. Dever, T.E., Feng, L., Wek, R.C., Cigan, A.M., Donahue, T.F., Hinnebusch, A.G. Cell (1992)
- Coupling of GCN4 mRNA translational activation with decreased rates of polypeptide chain initiation. Tzamarias, D., Roussou, I., Thireos, G. Cell (1989)
- A protein complex of translational regulators of GCN4 mRNA is the guanine nucleotide-exchange factor for translation initiation factor 2 in yeast. Cigan, A.M., Bushman, J.L., Boal, T.R., Hinnebusch, A.G. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Negative regulatory gene for general control of amino acid biosynthesis in Saccharomyces cerevisiae. Myers, P.L., Skvirsky, R.C., Greenberg, M.L., Greer, H. Mol. Cell. Biol. (1986)
- Multicopy tRNA genes functionally suppress mutations in yeast eIF-2 alpha kinase GCN2: evidence for separate pathways coupling GCN4 expression to unchanged tRNA. Vazquez de Aldana, C.R., Wek, R.C., Segundo, P.S., Truesdell, A.G., Hinnebusch, A.G. Mol. Cell. Biol. (1994)
- Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells. Sattlegger, E., Hinnebusch, A.G. EMBO J. (2000)
- GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2. Marton, M.J., Crouch, D., Hinnebusch, A.G. Mol. Cell. Biol. (1993)
- Polyribosome binding by GCN1 is required for full activation of eukaryotic translation initiation factor 2{alpha} kinase GCN2 during amino acid starvation. Sattlegger, E., Hinnebusch, A.G. J. Biol. Chem. (2005)
- Cloning of the cDNA of the heme-regulated eukaryotic initiation factor 2 alpha (eIF-2 alpha) kinase of rabbit reticulocytes: homology to yeast GCN2 protein kinase and human double-stranded-RNA-dependent eIF-2 alpha kinase. Chen, J.J., Throop, M.S., Gehrke, L., Kuo, I., Pal, J.K., Brodsky, M., London, I.M. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinase. Yang, R., Wek, S.A., Wek, R.C. Mol. Cell. Biol. (2000)
- Translation of the yeast transcriptional activator GCN4 is stimulated by purine limitation: implications for activation of the protein kinase GCN2. Rolfes, R.J., Hinnebusch, A.G. Mol. Cell. Biol. (1993)
- PKR and GCN2 kinases and guanine nucleotide exchange factor eukaryotic translation initiation factor 2B (eIF2B) recognize overlapping surfaces on eIF2alpha. Dey, M., Trieselmann, B., Locke, E.G., Lu, J., Cao, C., Dar, A.C., Krishnamoorthy, T., Dong, J., Sicheri, F., Dever, T.E. Mol. Cell. Biol. (2005)
- Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression. Wek, R.C., Ramirez, M., Jackson, B.M., Hinnebusch, A.G. Mol. Cell. Biol. (1990)
- Defects in tRNA processing and nuclear export induce GCN4 translation independently of phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. Qiu, H., Hu, C., Anderson, J., Björk, G.R., Sarkar, S., Hopper, A.K., Hinnebusch, A.G. Mol. Cell. Biol. (2000)
- Casein kinase II mediates multiple phosphorylation of Saccharomyces cerevisiae eIF-2 alpha (encoded by SUI2), which is required for optimal eIF-2 function in S. cerevisiae. Feng, L., Yoon, H., Donahue, T.F. Mol. Cell. Biol. (1994)
- GCN20, a novel ATP binding cassette protein, and GCN1 reside in a complex that mediates activation of the eIF-2 alpha kinase GCN2 in amino acid-starved cells. Vazquez de Aldana, C.R., Marton, M.J., Hinnebusch, A.G. EMBO J. (1995)
- The immunosuppressant FK506 uncovers a positive regulatory cross-talk between the Hog1p and Gcn2p pathways. Rodriguez-Hernandez, C.J., Sanchez-Perez, I., Gil-Mascarell, R., Rodríguez-Afonso, A., Torres, A., Perona, R., Murguia, J.R. J. Biol. Chem. (2003)
- YIH1 is an actin-binding protein that inhibits protein kinase GCN2 and impairs general amino acid control when overexpressed. Sattlegger, E., Swanson, M.J., Ashcraft, E.A., Jennings, J.L., Fekete, R.A., Link, A.J., Hinnebusch, A.G. J. Biol. Chem. (2004)
- Amino acid starvation and Gcn4p regulate adhesive growth and FLO11 gene expression in Saccharomyces cerevisiae. Braus, G.H., Grundmann, O., Brückner, S., Mösch, H.U. Mol. Biol. Cell (2003)
- Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases. Ramirez, M., Wek, R.C., Vazquez de Aldana, C.R., Jackson, B.M., Freeman, B., Hinnebusch, A.G. Mol. Cell. Biol. (1992)
- A hierarchy of trans-acting factors modulates translation of an activator of amino acid biosynthetic genes in Saccharomyces cerevisiae. Hinnebusch, A.G. Mol. Cell. Biol. (1985)
- Mutations in the GCD7 subunit of yeast guanine nucleotide exchange factor eIF-2B overcome the inhibitory effects of phosphorylated eIF-2 on translation initiation. Vazquez de Aldana, C.R., Hinnebusch, A.G. Mol. Cell. Biol. (1994)
- Dimerization by translation initiation factor 2 kinase GCN2 is mediated by interactions in the C-terminal ribosome-binding region and the protein kinase domain. Qiu, H., Garcia-Barrio, M.T., Hinnebusch, A.G. Mol. Cell. Biol. (1998)
- Ribosome association of GCN2 protein kinase, a translational activator of the GCN4 gene of Saccharomyces cerevisiae. Ramirez, M., Wek, R.C., Hinnebusch, A.G. Mol. Cell. Biol. (1991)
- Transcriptional-translational regulatory circuit in Saccharomyces cerevisiae which involves the GCN4 transcriptional activator and the GCN2 protein kinase. Roussou, I., Thireos, G., Hauge, B.M. Mol. Cell. Biol. (1988)
- Dimerization is required for activation of eIF2 kinase Gcn2 in response to diverse environmental stress conditions. Narasimhan, J., Staschke, K.A., Wek, R.C. J. Biol. Chem. (2004)