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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

RET2  -  Ret2p

Saccharomyces cerevisiae S288c

Synonyms: Coatomer subunit delta, Delta-COP, Delta-coat protein, YFR051C
 
 
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High impact information on RET2

  • The corresponding RET2 and RET3 genes were cloned by complementation and found of encode the delta and zeta subunits of coatomer respectively [1].
  • Last, we show that Dsl1p interacts with the delta-subunit of the retrograde COPI coat, Ret2p, and discuss possible roles for this interaction [2].
  • The C-terminal hydrophilic peptide of GMT that is exposed to the cytosol binds to Ret2p, a subunit of the COPI coat [3].
 

Anatomical context of RET2

  • Mutant peptide derivatives that have lost a cluster of lysine in the vicinity of the transmembrane domain had reduced binding activity to Ret2p and the GMT with this sequence was delivered to the vacuole [3].

References

  1. Delta- and zeta-COP, two coatomer subunits homologous to clathrin-associated proteins, are involved in ER retrieval. Cosson, P., Démollière, C., Hennecke, S., Duden, R., Letourneur, F. EMBO J. (1996) [Pubmed]
  2. Golgi-to-endoplasmic reticulum (ER) retrograde traffic in yeast requires Dsl1p, a component of the ER target site that interacts with a COPI coat subunit. Reilly, B.A., Kraynack, B.A., VanRheenen, S.M., Waters, M.G. Mol. Biol. Cell (2001) [Pubmed]
  3. Localization of GDP-mannose transporter in the Golgi requires retrieval to the endoplasmic reticulum depending on its cytoplasmic tail and coatomer. Abe, M., Noda, Y., Adachi, H., Yoda, K. J. Cell. Sci. (2004) [Pubmed]
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