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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

VPS13  -  Vps13p

Saccharomyces cerevisiae S288c

Synonyms: SOI1, Suppression of the onset of impotence protein 1, VPT2, Vacuolar protein sorting-associated protein 13, Vacuolar protein-targeting protein 2, ...
 
 
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High impact information on VPS13

  • Our results indicate that a significant fraction of polymerases starting transcription never make it to the end of a long GAL-VPS13 fusion gene [1].
  • These results suggested that Soi1p functions at two steps in the cycling of Kex2p and other proteins between the TGN and prevacuolar compartment (PVC) [2].
 

Biological context of VPS13

  • SOI1 suppressor alleles reduced the efficiency of localization of wild-type Kex2p to the TGN, implying an impaired ability to discriminate between the normal TLS and a mutant TLS. soi1 mutants also exhibited a recessive defect in vacuolar protein sorting [3].

References

  1. Evidence for distinct mechanisms facilitating transcript elongation through chromatin in vivo. Kristjuhan, A., Svejstrup, J.Q. EMBO J. (2004) [Pubmed]
  2. SOI1 encodes a novel, conserved protein that promotes TGN-endosomal cycling of Kex2p and other membrane proteins by modulating the function of two TGN localization signals. Brickner, J.H., Fuller, R.S. J. Cell Biol. (1997) [Pubmed]
  3. Allele-specific suppression of a defective trans-Golgi network (TGN) localization signal in Kex2p identifies three genes involved in localization of TGN transmembrane proteins. Redding, K., Brickner, J.H., Marschall, L.G., Nichols, J.W., Fuller, R.S. Mol. Cell. Biol. (1996) [Pubmed]
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