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Gene Review

RPL15A  -  ribosomal 60S subunit protein L15A

Saccharomyces cerevisiae S288c

Synonyms: 60S ribosomal protein L15-A, L13, RP15R, RPL10A, RPL13A, ...
 
 
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Disease relevance of RPL15A

 

High impact information on RPL15A

  • We show here that an L13 mutant extract cannot form stable base-pairing at room temperature but is permissive for U1-5'ss base-pairing at low temperature [2].
  • The L13 phenotype has therefore been interpreted to indicate that WT U1C contributes to 5'ss-U1 snRNA stabilization by binding to the RNA duplex [2].

References

  1. Disruption of the MRP-L23 gene encoding the mitochondrial ribosomal protein L23 is lethal for Kluyveromyces lactis but not for Saccharomyces cerevisiae. Murray, G.L., Bao, W.G., Fukuhara, H., Zuo, X.M., Clark-Walker, G.D., Chen, X.J. Curr. Genet. (2000) [Pubmed]
  2. Effects of the U1C L13 mutation and temperature regulation of yeast commitment complex formation. Du, H., Tardiff, D.F., Moore, M.J., Rosbash, M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
 
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