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Gene Review

D1Mit17  -  DNA segment, Chr 1, Massachusetts...

Mus musculus

Synonyms: Tgfbkm2, Tgfbm2
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High impact information on Tgfbm2

  • Tgfb1(-/-) survival to birth (STB), in addition to dependence on embryonic Tgfbkm2 genotype, also depends on maternal effects [1].
  • Experiments involving a congenic strain (B6.D2-Mtv7(a)/Ty) enabled more precise mapping of the chromosome 1 QTL and indicate that it lies in the genetic interval between markers D1Mit145 and D1Mit17 [2].
  • We have mapped Tlr5 to distal chromosome 1 using the (C57BL/6J x Mus spretus) x C57BL/6J Jackson BSB panel as well as a (C57BL/6J x MOLF/Ei)F(2) panel with the following position: D1Mit112-8.0 cM-Tlr5-9.6 cM-D1Mit17 [3].


  1. Genetic modifiers interact with maternal determinants in vascular development of Tgfb1(-/-) mice. Tang, Y., McKinnon, M.L., Leong, L.M., Rusholme, S.A., Wang, S., Akhurst, R.J. Hum. Mol. Genet. (2003) [Pubmed]
  2. Quantitative genetic study of maximal electroshock seizure threshold in mice: evidence for a major seizure susceptibility locus on distal chromosome 1. Ferraro, T.N., Golden, G.T., Smith, G.G., Longman, R.L., Snyder, R.L., DeMuth, D., Szpilzak, I., Mulholland, N., Eng, E., Lohoff, F.W., Buono, R.J., Berrettini, W.H. Genomics (2001) [Pubmed]
  3. Cloning and characterization of the murine toll-like receptor 5 (Tlr5) gene: sequence and mRNA expression studies in Salmonella-susceptible MOLF/Ei mice. Sebastiani, G., Leveque, G., Larivière, L., Laroche, L., Skamene, E., Gros, P., Malo, D. Genomics (2000) [Pubmed]
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