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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

DBP9  -  Dbp9p

Saccharomyces cerevisiae S288c

Synonyms: ATP-dependent RNA helicase DBP9, DEAD box protein 9, L9328.3, YLR276C
 
 
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Disease relevance of DBP9

  • To analyze the enzymatic characteristics of the protein, we expressed a recombinant Dbp9p in Escherichia coli and purified it to homogeneity [1].
 

High impact information on DBP9

  • Dbp9p seems to function in ribosomal RNA biogenesis, but it has not been biochemically characterized [1].
  • In addition, Dbp9p exhibited DNA-DNA and DNA-RNA helicase activity in the presence of ATP [1].
  • Furthermore, Dbp6p and Dbp9p weakly interact in a yeast two-hybrid assay [2].
  • Genetic depletion of Dbp9p results in a deficit in 60S ribosomal subunits and the appearance of half-mer polysomes [2].
 

Other interactions of DBP9

  • Altogether, our findings indicate an intimate functional interaction between Dbp6p and Dbp9p during the process of 60S-ribosomal-subunit assembly [2].

References

  1. Dbp9p, a member of the DEAD box protein family, exhibits DNA helicase activity. Kikuma, T., Ohtsu, M., Utsugi, T., Koga, S., Okuhara, K., Eki, T., Fujimori, F., Murakami, Y. J. Biol. Chem. (2004) [Pubmed]
  2. Dbp9p, a putative ATP-dependent RNA helicase involved in 60S-ribosomal-subunit biogenesis, functionally interacts with Dbp6p. Daugeron, M.C., Kressler, D., Linder, P. RNA (2001) [Pubmed]
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