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Gene Review:

RIF2 - Rif2p

Saccharomyces cerevisiae S288c

Synonyms: Protein RIF2, RAP1-interacting factor 2, YLR453C

Wotton, D. et al., Viscardi, V. et al., Levy, D.L. et al., Teixeira, M.T. et al.

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High impact information on RIF2

Deletion of the telomeric proteins Rif1 or Rif2 gives rise to longer telomeres by increasing the frequency of elongation events [1].
We have identified a new Rap1-interacting factor (Rif2p) that plays a role in telomere length regulation [2].
In genetic settings that cause telomeres to be abnormally long, tethering even a single Rif2p molecule was sufficient for maximal effectiveness in preventing the telomere overelongation [3].
Moreover, both telomere length rebalancing and checkpoint inactivation under galactose-induced conditions are accelerated by high levels of either the Sae2 protein, involved in double-strand breaks processing, or the negative telomere length regulator Rif2 [4].

Biological context of RIF2

However, deletion of both RIF1 and RIF2 in the same cell results in a dramatic increase in telomere length, similar to that seen with a carboxy-terminal truncation of Rap1p [2].

References

Telomere length homeostasis is achieved via a switch between telomerase- extendible and -nonextendible states. Teixeira, M.T., Arneric, M., Sperisen, P., Lingner, J. Cell (2004) [Pubmed]
A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae. Wotton, D., Shore, D. Genes Dev. (1997) [Pubmed]
Counting of Rif1p and Rif2p on Saccharomyces cerevisiae telomeres regulates telomere length. Levy, D.L., Blackburn, E.H. Mol. Cell. Biol. (2004) [Pubmed]
Sudden telomere lengthening triggers a Rad53-dependent checkpoint in Saccharomyces cerevisiae. Viscardi, V., Baroni, E., Romano, M., Lucchini, G., Longhese, M.P. Mol. Biol. Cell (2003) [Pubmed]

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