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Gene Review:

NUP60 - Nup60p

Saccharomyces cerevisiae S288c

Synonyms: FUN17, Nuclear pore protein NUP60, Nucleoporin NUP60, YAR002W

Denning, D. et al., Zhao, X. et al., Dilworth, D.J. et al.

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High impact information on NUP60

Here, we show that Mlps and Nup60, but not several other nucleoporins, are required to localize and stabilize a desumoylating enzyme Ulp1 [1].
On the nucleoplasmic face, where the Ran--GTP levels are predicted to be high, Nup2p binds to Nup60p [2].
The nucleoporin Nup60p functions as a Gsp1p-GTP-sensitive tether for Nup2p at the nuclear pore complex [3].
The nucleoporins Nup60p, Nup2p, and Nup1p form part of the nuclear basket structure of the Saccharomyces cerevisiae nuclear pore complex (NPC) [3].

Other interactions of NUP60

Yeast lacking Nup60p also fail to anchor Nup2p at the NPC, resulting in the mislocalization of Nup2p to the nucleoplasm and cytoplasm [3].

References

Mlp-dependent anchorage and stabilization of a desumoylating enzyme is required to prevent clonal lethality. Zhao, X., Wu, C.Y., Blobel, G. J. Cell Biol. (2004) [Pubmed]
Nup2p dynamically associates with the distal regions of the yeast nuclear pore complex. Dilworth, D.J., Suprapto, A., Padovan, J.C., Chait, B.T., Wozniak, R.W., Rout, M.P., Aitchison, J.D. J. Cell Biol. (2001) [Pubmed]
The nucleoporin Nup60p functions as a Gsp1p-GTP-sensitive tether for Nup2p at the nuclear pore complex. Denning, D., Mykytka, B., Allen, N.P., Huang, L., Al Burlingame, n.u.l.l., Rexach, M. J. Cell Biol. (2001) [Pubmed]

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