Gene Review:
GSP1 - Ran GTPase GSP1
Saccharomyces cerevisiae S288c
Synonyms:
CNR1, CST17, Chromosome stability protein 17, GTP-binding nuclear protein GSP1/CNR1, GTPase Ran homolog, ...
- RNA1 encodes a GTPase-activating protein specific for Gsp1p, the Ran/TC4 homologue of Saccharomyces cerevisiae. Becker, J., Melchior, F., Gerke, V., Bischoff, F.R., Ponstingl, H., Wittinghofer, A. J. Biol. Chem. (1995)
- Yeast heat shock mRNAs are exported through a distinct pathway defined by Rip1p. Saavedra, C.A., Hammell, C.M., Heath, C.V., Cole, C.N. Genes Dev. (1997)
- Cex1p is a novel cytoplasmic component of the Saccharomyces cerevisiae nuclear tRNA export machinery. McGuire, A.T., Mangroo, D. EMBO J. (2007)
- The nucleoporin Nup60p functions as a Gsp1p-GTP-sensitive tether for Nup2p at the nuclear pore complex. Denning, D., Mykytka, B., Allen, N.P., Huang, L., Al Burlingame, n.u.l.l., Rexach, M. J. Cell Biol. (2001)
- Mtr10p functions as a nuclear import receptor for the mRNA-binding protein Npl3p. Senger, B., Simos, G., Bischoff, F.R., Podtelejnikov, A., Mann, M., Hurt, E. EMBO J. (1998)
- Regulated nucleo/cytoplasmic exchange of HOG1 MAPK requires the importin beta homologs NMD5 and XPO1. Ferrigno, P., Posas, F., Koepp, D., Saito, H., Silver, P.A. EMBO J. (1998)
- GSP1 and GSP2, genetic suppressors of the prp20-1 mutant in Saccharomyces cerevisiae: GTP-binding proteins involved in the maintenance of nuclear organization. Belhumeur, P., Lee, A., Tam, R., DiPaolo, T., Fortin, N., Clark, M.W. Mol. Cell. Biol. (1993)
- Purification of protein A-tagged yeast ran reveals association with a novel karyopherin beta family member, Pdr6p. Lau, D., Künzler, M., Braunwarth, A., Hellmuth, K., Podtelejnikov, A., Mann, M., Hurt, E. J. Biol. Chem. (2000)
- Engineered mutants in the switch II loop of Ran define the contribution made by key residues to the interaction with nuclear transport factor 2 (NTF2) and the role of this interaction in nuclear protein import. Kent, H.M., Moore, M.S., Quimby, B.B., Baker, A.M., McCoy, A.J., Murphy, G.A., Corbett, A.H., Stewart, M. J. Mol. Biol. (1999)
- The small GTPase Gsp1p binds to the repeat domain of the nucleoporin Nsp1p. Stochaj, U., Héjazi, M., Belhumeur, P. Biochem. J. (1998)
- Mutants in a yeast Ran binding protein are defective in nuclear transport. Schlenstedt, G., Wong, D.H., Koepp, D.M., Silver, P.A. EMBO J. (1995)
- Yrb4p, a yeast ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus. Schlenstedt, G., Smirnova, E., Deane, R., Solsbacher, J., Kutay, U., Görlich, D., Ponstingl, H., Bischoff, F.R. EMBO J. (1997)
- Nuclear protein import, but not mRNA export, is defective in all Saccharomyces cerevisiae mutants that produce temperature-sensitive forms of the Ran GTPase homologue Gsp1p. Oki, M., Noguchi, E., Hayashi, N., Nishimoto, T. Mol. Gen. Genet. (1998)
- Allele-specific suppression of a Saccharomyces cerevisiae prp20 mutation by overexpression of a nuclear serine/threonine protein kinase. Fleischmann, M., Stagljar, I., Aebi, M. Mol. Gen. Genet. (1996)
- The GTP-bound form of the yeast Ran/TC4 homologue blocks nuclear protein import and appearance of poly(A)+ RNA in the cytoplasm. Schlenstedt, G., Saavedra, C., Loeb, J.D., Cole, C.N., Silver, P.A. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Yrb1p interaction with the gsp1p C terminus blocks Mog1p stimulation of GTP release from Gsp1p. Oki, M., Nishimoto, T. J. Biol. Chem. (2000)
- Interaction between the small GTPase Ran/Gsp1p and Ntf2p is required for nuclear transport. Wong, D.H., Corbett, A.H., Kent, H.M., Stewart, M., Silver, P.A. Mol. Cell. Biol. (1997)
- Yrb2p is a nuclear protein that interacts with Prp20p, a yeast Rcc1 homologue. Taura, T., Schlenstedt, G., Silver, P.A. J. Biol. Chem. (1997)
- A protein required for nuclear-protein import, Mog1p, directly interacts with GTP-Gsp1p, the Saccharomyces cerevisiae ran homologue. Oki, M., Nishimoto, T. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Saccharomyces cerevisiae putative G protein, Gtr1p, which forms complexes with itself and a novel protein designated as Gtr2p, negatively regulates the Ran/Gsp1p G protein cycle through Gtr2p. Nakashima, N., Noguchi, E., Nishimoto, T. Genetics (1999)
- Crystallization and preliminary X-ray diffraction analysis of the Saccharomyces cerevisiae ran-binding protein Mog1p. Baker, R.P., Stewart, M. Acta Crystallogr. D Biol. Crystallogr. (2000)
- Regulation of RNA processing and transport by a nuclear guanine nucleotide release protein and members of the Ras superfamily. Kadowaki, T., Goldfarb, D., Spitz, L.M., Tartakoff, A.M., Ohno, M. EMBO J. (1993)
- Yrb2p, a Nup2p-related yeast protein, has a functional overlap with Rna1p, a yeast Ran-GTPase-activating protein. Noguchi, E., Hayashi, N., Nakashima, N., Nishimoto, T. Mol. Cell. Biol. (1997)
- Overexpression of Bud5p can suppress mutations in the Gsp1p guanine nucleotide exchange factor Prp20p in Saccharomyces cerevisiae. Clément, M., Lavallée, F., Barbès-Morin, G., de Repentigny, L., Belhumeur, P. Mol. Genet. Genomics (2001)
- The nuclear GTPase Gsp1p can affect proper telomeric function through the Sir4 protein in Saccharomyces cerevisiae. Clément, M., Deshaies, F., de Repentigny, L., Belhumeur, P. Mol. Microbiol. (2006)