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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

GGC1  -  Ggc1p

Saccharomyces cerevisiae S288c

Synonyms: D1214, Mitochondrial GTP/GDP carrier protein 1, SHM1, YDL198C, YHM1
 
 
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High impact information on GGC1

  • These results suggest the SHM1p plays an accessory role to HM in the mitochondrion [1].
  • On glycerol medium, where mitochondrial function is required for growth, shm1 deletion mutants are able to grow whereas shm1 abf2 double mutants are severely inhibited [1].
  • The phenotypes of Delta yhm1 mutants indicate a role for this mitochondrial transporter in cellular iron homoeostasis [2].
  • Mutants of YHM1 converted into rho degrees, consistent with secondary mitochondrial DNA damage from mitochondrial iron accumulation [2].
  • The strain deleted for YHM1 was characterized by increased and misregulated surface ferric reductase and high-affinity ferrous transport activities [2].

References

  1. SHM1: a multicopy suppressor of a temperature-sensitive null mutation in the HMG1-like abf2 gene. Kao, L.R., Megraw, T.L., Chae, C.B. Yeast (1996) [Pubmed]
  2. Role of YHM1, encoding a mitochondrial carrier protein, in iron distribution of yeast. Lesuisse, E., Lyver, E.R., Knight, S.A., Dancis, A. Biochem. J. (2004) [Pubmed]
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