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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SNF11  -  Snf11p

Saccharomyces cerevisiae S288c

Synonyms: D4411, SWI/SNF complex component SNF11, Transcription regulatory protein SNF11, YDR073W
 
 
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Disease relevance of SNF11

  • Homology is conserved in five characteristic domains: an N-terminal domain that binds the SNF11 protein, a conserved domain A of unknown function, a central ATPase domain, a domain that binds the retinoblastoma tumor suppressor protein Rb, and a C-terminal bromodomain of unknown function [1].
 

High impact information on SNF11

  • SNF11 interacts with SNF2 in vitro and copurifies with the SNF-SWI complex from yeast cells [2].
  • In addition to SWI3, we recovered a new 19-kDa protein, designated SNF11 [2].
  • Furthermore, SNF11 was detected in purified SNF-SWI complex by staining with Coomassie blue dye; its presence previously went unrecognized because it does not stain with silver [2].
 

Other interactions of SNF11

  • SNF11, a new component of the yeast SNF-SWI complex that interacts with a conserved region of SNF2 [2].

References

  1. Isolation of cDNAs encoding chicken homologues of the yeast SNF2 and Drosophila Brahma proteins. Goodwin, G.H. Gene (1997) [Pubmed]
  2. SNF11, a new component of the yeast SNF-SWI complex that interacts with a conserved region of SNF2. Treich, I., Cairns, B.R., de los Santos, T., Brewster, E., Carlson, M. Mol. Cell. Biol. (1995) [Pubmed]
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