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Gene Review

SWI3  -  Swi3p

Saccharomyces cerevisiae S288c

Synonyms: HAF2, J0495, SWI/SNF complex subunit SWI3, TYE2, Transcription factor TYE2, ...
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Disease relevance of SWI3


High impact information on SWI3


Biological context of SWI3


Associations of SWI3 with chemical compounds

  • Furthermore TYE2 function seems to be important for the expression of a variety of Ty-unrelated functions such as ADH1 expression, sporulation, growth on maltose, galactose, raffinose, and on non-fermentable carbon sources [5].

Other interactions of SWI3

  • In addition to SWI3, we recovered a new 19-kDa protein, designated SNF11 [8].
  • The TYE2 gene was identified by recessive mutations which result in a significant reduction of Ty-mediated ADH2 expression [5].
  • The Swi1 and Swi3 proteins are required for mat1 imprinting and mating-type switching in Schizosaccharomyces pombe, where they mediate a pause of leading-strand replication in response to a lagging-strand signal [3].


  1. Fifteen open reading frames in a 30.8 kb region of the right arm of chromosome VI from Saccharomyces cerevisiae. Eki, T., Naitou, M., Hagiwara, H., Abe, M., Ozawa, M., Sasanuma, S., Sasanuma, M., Tsuchiya, Y., Shibata, T., Watanabe, K. Yeast (1996) [Pubmed]
  2. Essential role for the SANT domain in the functioning of multiple chromatin remodeling enzymes. Boyer, L.A., Langer, M.R., Crowley, K.A., Tan, S., Denu, J.M., Peterson, C.L. Mol. Cell (2002) [Pubmed]
  3. Schizosaccharomyces pombe Swi1, Swi3, and Hsk1 are components of a novel S-phase response pathway to alkylation damage. Sommariva, E., Pellny, T.K., Karahan, N., Kumar, S., Huberman, J.A., Dalgaard, J.Z. Mol. Cell. Biol. (2005) [Pubmed]
  4. Recruitment of SWI/SNF by Gcn4p does not require Snf2p or Gcn5p but depends strongly on SWI/SNF integrity, SRB mediator, and SAGA. Yoon, S., Qiu, H., Swanson, M.J., Hinnebusch, A.G. Mol. Cell. Biol. (2003) [Pubmed]
  5. Isolation of the TYE2 gene reveals its identity to SWI3 encoding a general transcription factor in Saccharomyces cerevisiae. Löhning, C., Rosenbaum, C., Ciriacy, M. Curr. Genet. (1993) [Pubmed]
  6. Srg3, a mouse homolog of yeast SWI3, is essential for early embryogenesis and involved in brain development. Kim, J.K., Huh, S.O., Choi, H., Lee, K.S., Shin, D., Lee, C., Nam, J.S., Kim, H., Chung, H., Lee, H.W., Park, S.D., Seong, R.H. Mol. Cell. Biol. (2001) [Pubmed]
  7. CHB2, a member of the SWI3 gene family, is a global regulator in Arabidopsis. Zhou, C., Miki, B., Wu, K. Plant Mol. Biol. (2003) [Pubmed]
  8. SNF11, a new component of the yeast SNF-SWI complex that interacts with a conserved region of SNF2. Treich, I., Cairns, B.R., de los Santos, T., Brewster, E., Carlson, M. Mol. Cell. Biol. (1995) [Pubmed]
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